Document Detail


Association between survivin -31G>C polymorphism and cancer risk: meta-analysis of 29 studies.
MedLine Citation:
PMID:  24077840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: A growing body of evidence has shown the possible relevance of survivin -31G>C (rs9904341) promoter polymorphism to the genetic susceptibility of cancer. Because of the lack of available conclusive data, we performed a meta-analysis of all relevant available studies to derive a more precise estimation of the relationship.
METHODS: A comprehensive literature search of Medline electronic database was conducted to collect relevant studies until August 18, 2013. References of the retrieved articles were also screened. The extracted data were statistically analyzed, and pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to estimate the association strength using Stata version 11.2 software.
RESULTS: A total of 29 studies with 7,473 cancer cases and 9,086 controls were included in the meta-analysis. Overall, the pooled analysis revealed that suvivin -31G>C polymorphism was significantly associated with increased cancer risk under multiple genetic models (CC vs. GG: OR = 1.37, 95 % CI 1.06–1.76; CC vs. CG: OR = 1.27, 95 % CI = 1.10–1.46; CC vs. CG + GG: OR = 1.31, 95 % CI = 1.10–1.57). In subgroup analysis with different cancer types, the -31G>C polymorphism significantly increased the risk of colorectal, gastric, and urothelial cancers, while this SNP remarkably decreased the susceptibility to hepatocellular carcinoma. Further stratification analysis by ethnicity showed an increasing cancer risk in the Asian population (CC vs. GG: OR = 1.61, 95 % CI 1.17–2.21; CC vs. CG: OR = 1.31, 95 % CI 1.12–1.53; CC vs. CG + GG: OR = 1.43, 95 % CI 1.16–1.77) but not in Europeans.
CONCLUSIONS: The survivin -31G>C polymorphism is associated with elevated cancer risk, especially among colorectal, gastric, and urothelial cancers and Asian populations.
Authors:
Qin Qin; Chi Zhang; Hongcheng Zhu; Xi Yang; Liping Xu; Jia Liu; Jing Lu; Liangliang Zhan; Hongyan Cheng; Xinchen Sun
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  140     ISSN:  1432-1335     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-02-28     Completed Date:  2014-03-25     Revised Date:  2014-04-18    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  179-88     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Genetic Predisposition to Disease
Humans
Inhibitor of Apoptosis Proteins / genetics*
Meta-Analysis as Topic
Neoplasms / etiology*
Polymorphism, Genetic / genetics*
Risk Factors
Chemical
Reg. No./Substance:
0/BIRC5 protein, human; 0/Inhibitor of Apoptosis Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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