| Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 21931224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The association between subclinical hypothyroidism (SCH) and microvascular complications of type 2 diabetes is unclear. We examined whether SCH is associated with diabetic retinopathy or nephropathy in Korean patients with type 2 diabetes. Data from 489 patients who visited the diabetes clinic at a university hospital between 2001 and 2007 were analyzed retrospectively. Participants were evaluated for glycemic control, thyroid function, and diabetic retinopathy and nephropathy. Diabetic retinopathy was classified into five grades. Diabetic nephropathy was assessed by the presence of albuminuria. Patients in the SCH group had a higher proportion of women, older age, longer duration of diabetes, higher systolic and diastolic blood pressure, and higher insulin resistance index compared with the euthyroid group. No significant difference in family history of diabetes or body mass index was found between groups. The prevalence of severe diabetic retinopathy (severe nonproliferative diabetic retinopathy or proliferative diabetic retinopathy) was significantly higher in the SCH group than the euthyroid group (32.8% vs. 19.6%, P = 0.036), whereas no between-group difference was found in the prevalence of diabetic nephropathy. After adjustment for potential confounding factors (HbA1c, BMI, duration of diabetes, diabetic nephropathy, and hypertension) by multivariate logistic regression analysis, SCH remained significantly associated with severe diabetic retinopathy (odds ratio 2.086 (95% CI, 1.010-4.307), P = 0.047). These results suggest that SCH was independently associated with severe diabetic retinopathy in patients with type 2 diabetes. Further prospective studies are required to confirm the association between SCH and diabetic retinopathy. |
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Authors:
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Bo-Yeon Kim; Chul-Hee Kim; Chan-Hee Jung; Ji-Oh Mok; Kyo-Il Suh; Sung-Koo Kang |
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Publication Detail:
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Type: Journal Article Date: 2011-09-17 |
Journal Detail:
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Title: Endocrine journal Volume: 58 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-27 Completed Date: 2012-04-24 Revised Date: 2012-05-03 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 1065-70 Citation Subset: IM |
Affiliation:
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Division of Endocrinology & Metabolism, Department of Internal Medicine, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Asian Continental Ancestry Group Diabetes Mellitus, Type 2 / complications* Diabetic Nephropathies / epidemiology, etiology Diabetic Retinopathy / complications, epidemiology, etiology* Female Humans Hypothyroidism / complications*, epidemiology Male Middle Aged Prevalence Republic of Korea / epidemiology Retrospective Studies |
| Comments/Corrections | |
Comment In:
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Endocr J. 2011;58(12):1105-6
[PMID:
22056523
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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