Document Detail


Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.
MedLine Citation:
PMID:  18179391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impulsivity is a personality trait characterized by acting suddenly in an unplanned manner in order to satisfy a desire without consideration for the consequences of such behavior. There are several psychiatric disorders that include the term impulsivity as a criterion and, therefore, it has been suggested that impulsivity may be an important phenotype that may link a number of different behavioral disorders, including substance abuse. This study's aims were to determine if a significant association could be detected between the (AAT)n triplet repeat polymorphism as well as 5 single nucleotide polymorphisms (SNPs) in or near the CNR1 receptor gene and impulsivity in Southwest California 'Mission' Indians (SWC). Impulsivity was assessed using a scale derived from the Maudsley personality inventory, and blood samples were collected for DNA analyses from 251 individuals recruited from local Indian reservations. The estimated heritability (h(2)) for the impulsivity phenotype was 0.20 + 0.12 (p < .004). Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians.
Authors:
Cindy L Ehlers; Wendy S Slutske; Penelope A Lind; K C Wilhelmsen
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  10     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-08     Completed Date:  2008-02-01     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  805-11     Citation Subset:  IM    
Affiliation:
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. cindye@scripps.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Base Sequence
California
DNA Primers / genetics
Female
Humans
Impulsive Behavior / genetics*
Indians, North American / genetics*,  psychology*
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide*
Receptor, Cannabinoid, CB1 / genetics*
Trinucleotide Repeats
Grant Support
ID/Acronym/Agency:
5 R01 DA019333/DA/NIDA NIH HHS; 5 R37 AA010201/AA/NIAAA NIH HHS; R01 AA010201/AA/NIAAA NIH HHS; R01 DA019333/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Receptor, Cannabinoid, CB1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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