Document Detail

Association between short interpregnancy intervals and term birth weight: the role of folate depletion.
MedLine Citation:
PMID:  18614735     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Maternal folate depletion has been proposed as a primary explanation for the excess risk of fetal growth restriction associated with short interpregnancy intervals. OBJECTIVE: We aimed to evaluate the folate depletion hypothesis in a community-based cohort of pregnant women. DESIGN: Using a subsample of the cohort (multiparous participants who delivered a liveborn singleton infant, n = 3153), we investigated the relation between an increase in the interpregnancy interval (from 1 to 24 mo, natural log transformation) and birth weight and the risk of small-for-gestational-age (SGA) in 3 strata of maternal periconceptional folic acid use: nonuse, late use (begun after conception), and early use (begun before conception). RESULTS: Each increase in the interpregnancy interval on the natural log (ln) scale was associated with a mean (+/-SE) increase of 63.1 +/- 20.3 g in birth weight (P = 0.002). This relation was mitigated by folic acid use: the change in birth weight was increases of 165.2 +/- 39.6 g for nonuse (P < 0.001) and 33.5 +/- 35.6 g for late use (P = 0.347) and a decrease of 5.9 +/- 33.6 g for early use (P = 0.861). The birth weight differences were directly translated into SGA risk. Odds ratios per 1-mo increase in ln(interpregnancy interval) were significant for the total group (0.61; 95% CI: 0.46, 0.82) and for nonuse (0.38; 0.24, 0.60) and nonsignificant for late (0.83; 0.48, 1.44) and early (1.28; 0.58, 2.84) use. CONCLUSIONS: Folate depletion apparently contributes to the excess risk of fetal growth restriction that is associated with short interpregnancy intervals. As a preventive option, postnatal supplementation may be beneficial, but confirmation is needed.
Manon van Eijsden; Luc J M Smits; Marcel F van der Wal; Gouke J Bonsel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  88     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-10     Completed Date:  2008-07-31     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  AIM; IM    
Department of Epidemiology, Documentation and Health Promotion, Municipal Health Service, Amsterdam, The Netherlands.
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MeSH Terms
Birth Intervals*
Birth Weight / drug effects*,  physiology
Cohort Studies
Dietary Supplements
Folic Acid / administration & dosage*,  blood
Folic Acid Deficiency / blood*,  complications,  epidemiology
Infant, Newborn
Infant, Small for Gestational Age*
Maternal Nutritional Physiological Phenomena / physiology*
Pregnancy Outcome
Prenatal Care
Prenatal Nutritional Physiological Phenomena
Prospective Studies
Risk Factors
Time Factors
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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