| Association between short interpregnancy intervals and term birth weight: the role of folate depletion. | |
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MedLine Citation:
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PMID: 18614735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Maternal folate depletion has been proposed as a primary explanation for the excess risk of fetal growth restriction associated with short interpregnancy intervals. OBJECTIVE: We aimed to evaluate the folate depletion hypothesis in a community-based cohort of pregnant women. DESIGN: Using a subsample of the cohort (multiparous participants who delivered a liveborn singleton infant, n = 3153), we investigated the relation between an increase in the interpregnancy interval (from 1 to 24 mo, natural log transformation) and birth weight and the risk of small-for-gestational-age (SGA) in 3 strata of maternal periconceptional folic acid use: nonuse, late use (begun after conception), and early use (begun before conception). RESULTS: Each increase in the interpregnancy interval on the natural log (ln) scale was associated with a mean (+/-SE) increase of 63.1 +/- 20.3 g in birth weight (P = 0.002). This relation was mitigated by folic acid use: the change in birth weight was increases of 165.2 +/- 39.6 g for nonuse (P < 0.001) and 33.5 +/- 35.6 g for late use (P = 0.347) and a decrease of 5.9 +/- 33.6 g for early use (P = 0.861). The birth weight differences were directly translated into SGA risk. Odds ratios per 1-mo increase in ln(interpregnancy interval) were significant for the total group (0.61; 95% CI: 0.46, 0.82) and for nonuse (0.38; 0.24, 0.60) and nonsignificant for late (0.83; 0.48, 1.44) and early (1.28; 0.58, 2.84) use. CONCLUSIONS: Folate depletion apparently contributes to the excess risk of fetal growth restriction that is associated with short interpregnancy intervals. As a preventive option, postnatal supplementation may be beneficial, but confirmation is needed. |
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Authors:
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Manon van Eijsden; Luc J M Smits; Marcel F van der Wal; Gouke J Bonsel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 88 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-10 Completed Date: 2008-07-31 Revised Date: 2009-05-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 147-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology, Documentation and Health Promotion, Municipal Health Service, Amsterdam, The Netherlands. mveijsden@ggd.amsterdam.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Intervals* Birth Weight / drug effects*, physiology Cohort Studies Dietary Supplements Female Folic Acid / administration & dosage*, blood Folic Acid Deficiency / blood*, complications, epidemiology Humans Infant, Newborn Infant, Small for Gestational Age* Male Maternal Nutritional Physiological Phenomena / physiology* Pregnancy Pregnancy Outcome Prenatal Care Prenatal Nutritional Physiological Phenomena Prospective Studies Risk Factors Time Factors |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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