Document Detail

Association between the seven-repeat allele of the dopamine-4 receptor gene (DRD4) and spontaneous food intake in pre-school children.
MedLine Citation:
PMID:  24153108     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies in adults show associations between the hypofunctional seven-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), increased eating behaviour and/or obesity, particularly in females. We examined whether 7R is associated with total caloric intake and/or food choices in pre-schoolers.
METHODS: 150 four-year-old children taking part in a birth cohort study in Canada were administered a snack test meal in a laboratory setting. Mothers also filled out a food frequency questionnaire to address childrens' habitual food consumption. Total caloric and individual macronutrient intakes during the snack meal and specific types of foods as reported in the food diaries were compared across 7R allele carriers vs. non-carriers, using current BMI as a co-variate.
RESULTS: We found significant sex by genotype interactions for fat and protein intake during the snack test. Post hoc testing revealed that in girls, but not boys, 7R carriers ate more fat and protein than did non-carriers. Based on the food diaries, across both sexes, 7R carriers consumed more portions of ice cream and less vegetables, eggs, nuts and whole bread, suggesting a less healthy pattern of habitual food consumption.
CONCLUSION: The 7R allele of DRD4 influences macronutrient intakes and specific food choices as early as four years of age. The specific pattern of results further suggests that prior associations between the 7R allele and adult overeating/obesity may originate in food choices observable in the preschool years. Longitudinal follow-up of these children will help establish the relevance of these findings for obesity risk and prevention.
Patrícia Pelufo Silveira; André Krumel Portella; James L Kennedy; Hélène Gaudreau; Caroline Davis; Meir Steiner; Claudio N Soares; Stephen G Matthews; Marla B Sokolowski; Laurette Dubé; Eric B Loucks; Jill Hamilton; Michael J Meaney; Robert D Levitan;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-10-20
Journal Detail:
Title:  Appetite     Volume:  73     ISSN:  1095-8304     ISO Abbreviation:  Appetite     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2013-12-24     Completed Date:  2014-07-28     Revised Date:  2014-10-07    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Body Mass Index
Child, Preschool
Energy Intake / genetics*
Food Habits*
Food Preferences*
Hyperphagia / genetics
Obesity / genetics*
Receptors, Dopamine D4 / genetics*
Sex Factors
Grant Support
200610CFE-170826-164844//Canadian Institutes of Health Research; R01 HD061973/HD/NICHD NIH HHS; R24 HD041020/HD/NICHD NIH HHS; U01 HD061973/HD/NICHD NIH HHS
Reg. No./Substance:
137750-34-6/Receptors, Dopamine D4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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