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Association between serum uric acid and atrial fibrillation: A systematic review and meta-analysis: Uric acid and atrial fibrillation.
MedLine Citation:
PMID:  24709288     Owner:  NLM     Status:  Publisher    
BACKGROUND: Atrial fibrillation (AF) is mediated by oxidative stress, neurohormonal and inflammatory activation. Serum uric acid (SUA) is a surrogate marker of oxidative stress. Xanthine oxidase (XO) produces SUA and is upregulated by inflammation and neurohormones.
OBJECTIVE: The purpose of this study was to perform a meta-analysis to evaluate the evidence supporting an association between AF and SUA.
METHODS: We searched the MEDLINE database (1966 to July 2013) supplemented by manual searches of bibliographies of key relevant articles. We selected all cross-sectional and cohort studies in which SUA was measured and AF was reported. We calculated in cross-sectional studies the pooled standardized mean difference (SMD) of SUA between those with and without AF. In cohort studies we calculated the pooled relative risk (RR) with the corresponding 95% confidence interval (CI) for incident AF using the random-effects method.
RESULTS: The search strategy yielded 40 studies, of which only 9 met our eligibility criteria. The 6 cross-sectional studies comprised 7930 evaluable patients with a median prevalence of heart failure of 4% (range 0-100). The SMD of SUA for those with AF was 0.42; 95% CI 0.27-0.58 when compared to those without AF. The three cohort studies evaluated 138,306 subjects free of AF. The RR of having AF for those with high SUA was 1.67 (95% CI 1.23-2.27) when compared to those with normal SUA.
CONCLUSIONS: High serum uric acid is associated with AF in both cross-sectional and cohort studies. It is unclear if SUA represents a disease marker or a treatment target.
Leonardo Tamariz; Fernando Hernandez; Aaron Bush; Ana Palacio; Joshua M Hare
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-4
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  -     ISSN:  1556-3871     ISO Abbreviation:  Heart Rhythm     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
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