Document Detail

Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals.
MedLine Citation:
PMID:  15746438     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: There are few data available on possible independent association between uric acid and carotid atherosclerosis. Here we first sought to investigate association between uric acid levels and metabolic syndrome in Japanese; second, we assessed whether there is an independent association of uric acid with prevalence of carotid atherosclerosis in individuals subdivided according to gender and metabolic syndrome status. METHODS AND RESULTS: Cross-sectional data from 8144 individuals who underwent general health screening were analyzed. After adjusting for age, total cholesterol, and smoking status, the odds ratios (95% CI) of sex-specific quartiles of serum uric acid for metabolic syndrome were 1.0, 1.06 (0.60 to 1.87), 2.18 (1.30 to 3.64), and 4.17 (2.56 to 6.79) in women, and 1.0, 0.92 (0.74 to 1.14), 1.52 (1.25 to 1.65), and 1.97 (1.61 to 2.40) in men. After adjusting for age, serum levels, total cholesterol, and smoking status, prevalence of carotid plaque was higher in subjects in the second, third, and fourth quartiles of uric acid level with odds ratios (95% CI) of 1.24 (1.01 to 1.52), 1.37 (1.11 to 1.68), and 1.31 (1.05 to 1.63), respectively, in men without metabolic syndrome but not in men with metabolic syndrome or in women with or without metabolic syndrome. CONCLUSIONS: The prevalence of metabolic syndrome showed a graded increase according to serum uric acid values in both genders. In men who did not have metabolic syndrome, uric acid was found to be an independent risk factor for incidence of carotid plaque.
Nobukazu Ishizaka; Yuko Ishizaka; Ei-Ichi Toda; Ryozo Nagai; Minoru Yamakado
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Publication Detail:
Type:  Journal Article     Date:  2005-03-03
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  25     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1038-44     Citation Subset:  IM    
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Asian Continental Ancestry Group / statistics & numerical data
Bilirubin / blood
Carotid Artery Diseases / blood*,  ethnology*,  pathology
Cross-Sectional Studies
Japan / epidemiology
Metabolic Syndrome X / blood*,  ethnology*
Middle Aged
Multivariate Analysis
Risk Factors
Sex Distribution
Uric Acid / blood*
Reg. No./Substance:
635-65-4/Bilirubin; 69-93-2/Uric Acid

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