Document Detail


Association between serum uric acid level and metabolic syndrome.
MedLine Citation:
PMID:  22712045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Serum uric acid levels have been reported to be associated with a variety of cardiovascular conditions. However, the direct association between uric acid levels and metabolic syndrome remains controversial. Thus, we evaluated the association of serum uric acid levels and metabolic syndrome in a community-based cohort study in Korea.
METHODS: We performed cross-sectional analysis of baseline data of 889 males and 1491 females (aged 38 to 87) who participated in baseline examinations of the Korean Genome and Epidemiology Study: Kanghwa study. Blood samples were collected after at least an 8 hour fast. Uric acid quartiles were defined as follows: <4.8, 4.8-<5.6, 5.6-<6.5, ≥6.5 mg/dL in males; and <3.8, 3.8-<4.3, 4.3-<5.1, ≥5.1 mg/dL in females. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III Criteria with adjusted waist circumference cutoffs (90 cm for males; 80 cm for females). The association between serum uric acid quartiles and metabolic syndrome was assessed using multivariate logistic regression.
RESULTS: The odds ratio for having metabolic syndrome in the highest versus lowest quartiles of serum uric acid levels was 2.67 (95% confidence interval [CI], 1.60 to 4.46) in males and 2.14 (95% CI, 1.50 to 3.05) in females after adjusting for age, smoking, alcohol intake, body mass index, total cholesterol, HbA1c, albumin, γ-glutamyltransferase, blood urea nitrogen, and log C-reactive protein. The number of metabolic abnormalities also increased gradually with increasing serum uric acid levels (adjusted p for trend < 0.001 in both sexes).
CONCLUSIONS: Higher serum uric acid levels are positively associated with the presence of metabolic syndrome in Korean males and females.
Authors:
Ju-Mi Lee; Hyeon Chang Kim; Hye Min Cho; Sun Min Oh; Dong Phil Choi; Il Suh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-31
Journal Detail:
Title:  Journal of preventive medicine and public health = Yebang Ŭihakhoe chi     Volume:  45     ISSN:  2233-4521     ISO Abbreviation:  J Prev Med Public Health     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-19     Completed Date:  2012-11-13     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101242972     Medline TA:  J Prev Med Public Health     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
Affiliation:
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers / blood
Cohort Studies
Cross-Sectional Studies
Female
Humans
Hyperuricemia / blood*
Inflammation
Logistic Models
Male
Metabolic Syndrome X / blood*
Middle Aged
Odds Ratio
Prospective Studies
Republic of Korea
Risk Assessment
Rural Health
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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