| Association between scanning laser polarimetry measurements using variable corneal polarization compensation and visual field sensitivity in glaucomatous eyes. | |
| | |
MedLine Citation:
|
PMID: 12860798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare the association between scanning laser polarimetry (SLP) retinal nerve fiber layer (RNFL) measurements and automated perimetry sensitivity using both SLP manufacturer-assumed fixed and subject-specific variable corneal polarization magnitude and corneal polarization axis values. METHODS: An SLP was modified to enable the measurement of corneal polarization magnitude and corneal polarization axis so that compensation for corneal birefringence could be corrected on a subject-specific variable basis. Seventy-three eyes from the University of California, San Diego, Diagnostic Innovations in Glaucoma Study with early glaucoma or suspected glaucoma (abnormal Swedish Interactive Threshold Algorithm [SITA] or full-threshold automated perimetry results and/or glaucomatous-appearing optic disc by consensus grading of stereoscopic optic disc photographs) (mean [SD] SITA mean deviation, -2.74 [3.71] dB; range, 1.72 to -14.72 dB) were included. Subjects were imaged with SLP using the manufacturer-assumed fixed corneal compensation values and subject-specific variable corneal compensation values and tested with SITA automated perimetry. Scanning laser polarimetry and SITA data were obtained within 3 months of each other. MAIN OUTCOME MEASURES: The relationship between regional SLP RNFL measurements (24 parameters) and corresponding regional SITA raw thresholds were evaluated using linear regression for both (fixed corneal compensation and variable corneal compensation) SLP configurations. RESULTS: No fixed corneal compensation SLP measurements were significantly associated with corresponding SITA visual field zone sensitivities after corrections for multiple comparisons. Seven variable corneal compensation RNFL parameters (superior, inferior, or mean RNFL thickness measurements) were significantly associated with their corresponding visual field zones with R2 values ranging from 0.13 (ellipse average) to 0.20 (superior average). CONCLUSION: Variable corneal compensation to correct for subject-specific corneal polarization magnitude and corneal polarization axis improves the relationship between SLP-measured RNFL thickness and visual function measured by SITA perimetry. |
| | |
Authors:
|
Christopher Bowd; Linda M Zangwill; Robert N Weinreb |
Related Documents
:
|
11567958 - Study of retinal nerve fibre layer thickness in eyes with high tension glaucoma and hem... 17504858 - Association between integrity of foveal photoreceptor layer and visual acuity in branch... 17992198 - Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclero... 16925718 - Optical coherence tomography findings in commotio retina. 12700718 - Heat loss, sleepiness, and impaired performance after diazepam administration in humans. 23347368 - Results of corneal collagen cross-linking in pediatric patients. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Archives of ophthalmology Volume: 121 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-07-15 Completed Date: 2003-08-05 Revised Date: 2010-12-17 |
Medline Journal Info:
|
Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
|
Languages: eng Pagination: 961-6 Citation Subset: AIM; IM |
Affiliation:
|
Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla 92093-0946, USA. cbowd@eyecenter.ucsd.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Algorithms Birefringence Cornea / physiology* Female Glaucoma / physiopathology* Humans Lasers / diagnostic use Male Middle Aged Nerve Fibers / pathology Ocular Hypertension / physiopathology Optic Disk / pathology Retinal Ganglion Cells / pathology Sensitivity and Specificity Visual Field Tests / methods* Visual Fields / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
EY11008/EY/NEI NIH HHS; R01 EY011008-07/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective laser trabeculoplasty as primary treatment for open-angle glaucoma: a prospective, nonrand...
Next Document: Resonance Raman measurement of macular carotenoids in retinal, choroidal, and macular dystrophies.