| Association between sRAGE, esRAGE levels and vascular inflammation: Analysis with (18)F-fluorodeoxyglucose positron emission tomography. | |
| | |
MedLine Citation:
|
PMID: 22137663 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory RAGE (esRAGE), may neutralize AGE-RAGE mediated vascular damage by acting as a decoy. (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel imaging technique for detecting vascular inflammation. METHODS: We examined vascular inflammation measured using FDG-PET in 41 type 2 diabetes patients and 41 healthy control subjects in the right carotid artery. Vascular (18)F-FDG uptake was measured as the blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). In addition, their relationship with carotid intima-media thickness (CIMT), estimated GFR (eGFR), and other cardiovascular risk factors was evaluated. RESULTS: Both mean and maximum TBR values were significantly higher in patients with type 2 diabetes compared to healthy subjects. After adjusting for age and gender, sRAGE levels were significantly correlated with both mean and maximum TBR values, but not with CIMT values. Multiple linear regression analysis showed that maximum TBR values were independently associated with sRAGE levels in addition to HbA1c and eGFR. CONCLUSIONS: Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation. |
| | |
Authors:
|
Sae Jeong Yang; Seongeun Kim; Soon Young Hwang; Tae Nyun Kim; Hae Yoon Choi; Hye Jin Yoo; Ji A Seo; Sin Gon Kim; Nan Hee Kim; Sei Hyun Baik; Dong Seop Choi; Kyung Mook Choi |
Related Documents
:
|
19698063 - Evaluation of the 24-hour profiles of physiological insulin, glucose, and c-peptide in ... 9924263 - African plant foods rich in non-starch polysaccharides reduce postprandial blood glucos... 20511703 - Myocardial iron metabolism in the regulation of cardiovascular diseases in rats. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
|
Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
From the Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Facile synthesis of carbon-11-labeled arylpiperazinylthioalkyl derivatives as new PET radioligands f...
Next Document: The urokinase system in the pathogenesis of atherosclerosis.