| Association between regional cerebral blood flow during hypoglycemia and genetic and phenotypic traits of the renin-angiotensin system. | |
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MedLine Citation:
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PMID: 19584889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The risk of severe hypoglycemia in patients with type I diabetes and high basal activity in the renin-angiotensin system (RAS) is significantly higher than in patients with low basal RAS activity. In healthy men, we tested the hypothesis that differences in spontaneous RAS activity are associated with differences in cerebral activity responses during mild hypoglycemia. A total of 10 healthy men with high and 10 with low spontaneous RAS activity were selected. An H(2)(15)O-PET (H(2)(15)O-positron emission tomography) study was conducted with a series of six scans, i.e., two during normoglycemia, two during hypoglycemia, and two after hypoglycemia. The mean plasma glucose concentration was similar in both the groups (i.e., 2.1 mmol/L (s.d.: 0.4) in the low RAS group and 2.2 mmol/L (s.d.: 0.4) in the high RAS group (P=0.47)). The high RAS group has lower cerebral activity in the frontal area and a higher cerebral activity in the entorhinal area that expanded to include the parahippocampal gyrus after hypoglycemia. Our findings suggest that the high RAS group to a lesser extent than the low RAS group activates areas involving executive function that may explain the correlation between high basal RAS activity and risk of severe hypoglycemia in type I diabetes. |
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Authors:
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Lise Grimmeshave Bie-Olsen; Ulrik Pedersen-Bjergaard; Troels Wesenberg Kjaer; Markus Nowak Lonsdale; Ian Law; Birger Thorsteinsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-08 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 29 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1790-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Endocrinology, Endocrinology Section, Hillerød Hospital, Hillerød, Denmark. ligri@noh.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensinogen / blood Blood Glucose / analysis Brain / blood supply*, metabolism, physiopathology Cerebrovascular Circulation / physiology* Humans Hypoglycemia / genetics, metabolism, physiopathology* Hypoglycemic Agents / administration & dosage Insulin / administration & dosage Male Peptidyl-Dipeptidase A / blood Phenotype Polymorphism, Single Nucleotide Positron-Emission Tomography Receptor, Angiotensin, Type 2 / genetics Renin-Angiotensin System / genetics*, physiology* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Receptor, Angiotensin, Type 2; 11002-13-4/Angiotensinogen; 11061-68-0/Insulin; EC 3.4.15.1/Peptidyl-Dipeptidase A |
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