Document Detail


Association between reactive oxygen species and disease activity in chronic hepatitis C.
MedLine Citation:
PMID:  8855439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reactive Oxygen Species (ROS) may be involved in the damage occurring in the course of chronic HCV infection. Individuals with chronic hepatitis C present increased hepatic levels of malondialdehyde (MDA) and reduced levels of glutathione. To determine whether these observations are associated with serological evidence for ROS injury, MDA and protein carbonyl content (PCC) of serum was determined in 20 HCV positive patients (14 chronic active hepatitis -- CAH and 6 cirrhosis) and 20 controls. Compared to controls, HCV positive subjects had increased levels of MDA (13.33 +/- 0.21 SE ng/ml vs. 9.90 +/- 0.65 P < .05) and PCC (4.74 +/- 0.21 mmol/mg vs 3.68 +/- 0.21, p < .02). Patients with CAH had higher levels than did cirrhotics. Both MDA and PCC correlated with serum ALT levels (r = .792 and r = .818 respectively, p < .001). A common origin for MDA and PCC found in patients with chronic hepatitis C was suggested by the correlation between the two measures (r = .741, p < .001). No correlation were found between MDA or PCC and the hepatic iron content. These data demonstrate that: (1) lipid and protein oxidation occur in chronic hepatitis C, (2) oxidative damage can be demonstrated as increased serum levels of MDA and PCC, and (3) both MDA and PCC levels correlate with disease activity.
Authors:
N De Maria; A Colantoni; S Fagiuoli; G J Liu; B K Rogers; F Farinati; D H Van Thiel; R A Floyd
Related Documents :
10825999 - Viral hepatitis c.
8685959 - Azathioprine hepatitis in kidney transplant recipients. a predisposing role of chronic ...
21781419 - Adherence to tablet and liquid formulations of antiretroviral medication for paediatric...
1653749 - Hepatitis c virus antibodies in acute icteric and chronic non-a, non-b hepatitis.
18159509 - The management of chronic viral hepatitis: a canadian consensus conference 2004.
10622559 - Liver biopsy in hepatitis c.
9448149 - Interferon-alpha for prophylaxis of recurrent viral hepatitis c in liver transplant rec...
18362039 - Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis c viru...
11182499 - Seroepidemiology of mycoplasma hyopneumoniae in pigs from farrow-to-finish farms.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  21     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-27     Completed Date:  1996-12-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Affiliation:
Liver Disease Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Proteins / metabolism
Chronic Disease
Female
Glutathione / metabolism
Hepatitis C / metabolism*
Humans
Liver / metabolism
Male
Malondialdehyde / blood,  metabolism
Middle Aged
Reactive Oxygen Species / metabolism*
Grant Support
ID/Acronym/Agency:
HL 53585/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Reactive Oxygen Species; 542-78-9/Malondialdehyde; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Direct detection and identification of radicals generated during the hydroxyl radical-induced degrad...
Next Document:  Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate...