Document Detail


Association between proliferative scars and in-stent restenosis.
MedLine Citation:
PMID:  18042333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Keloid and hypertrophic scars are two types of proliferative scars at sites of cutaneous injury that form as a result of an abnormal wound-healing process. Proliferative scar formation after skin injury and restenosis after coronary stenting have common features. The aim of this study was to investigate the association of proliferative scars with coronary stent restenosis. METHODS: Patients with previous open heart surgery with median sternotomy who had coronary stenting after the surgery and were admitted for control angiography were included in the study. The patients were divided into two groups according to the presence or absence of proliferative scars. The primary end point was the incidence of angiographic restenosis in patient groups. RESULTS: The study group consisted of 80 patients (64 men; mean age 64 + or - 9 years). Twenty-three patients (29%) have a proliferative scar. In general, two groups were comparable with regard to baseline lipid profiles, demographics, and cardiovascular risk factors. Restenosis was significantly more prevalent in patients with proliferative scars than with controls (p = .04). By multivariate logistic regression analysis, stent length (odds ratio [OR] 1.12, p = .005), diabetes (OR 3.3, p = .03), and proliferative scar (OR 4.2, p = .02) independently predicted in-stent restenosis. CONCLUSION: The findings of this study suggest that patients with proliferative scars may have a higher risk of in-stent restenosis.
Authors:
Cagdas Ozdol; Sibel Turhan; Cansin Tulunay; A Timucin Altin; Yusuf Atmaca; Basar Candemir; Cetin Erol
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  11     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-11-28     Completed Date:  2008-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  206-10     Citation Subset:  IM    
Affiliation:
Cardiology Department, Ankara University School of Medicine, Ankara, Turkey. cagdas_2005@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Cicatrix, Hypertrophic / etiology*
Coronary Angiography
Coronary Restenosis / etiology*
Female
Humans
Incidence
Male
Middle Aged
Risk Factors
Stents*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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