| THE ASSOCIATION BETWEEN PORPHYRIA CUTANEA TARDA AND DIABETES MELLITUS. | |
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MedLine Citation:
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PMID: 21564073 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: An association between porphyria cutanea tarda (PCT) and diabetes mellitus (DM) is widely-reported, but the pathogenetic link remains unknown. Objective: To investigate the natural history of DM in the setting of PCT and which PCT features and risk factors may be associated with the development of DM. Methods: This retrospective longitudinal study included 81 Spanish patients with PCT with at least 10 years of strict follow-up. Patients attended our Porphyria Unit for follow-up visits and the data were collected in the period 2004-2008. We classified patients into two groups: patients with glucose metabolism alterations (GMA) [DM or impaired fasting glucose (IFG)], and patients without. PCT features and PCT and DM risk factors were retrieved from clinical charts and compared between groups. Results: We identified 33 patients (40.7%) with GMA, of whom 81.8% developed GMA a long time after the diagnosis of PCT (mean: 12.7 years). In the bivariate analysis, these patients had significantly higher mean serum ferritin at diagnosis (651 vs 405 ng/mL, p = 0.005), a higher prevalence of persistently-elevated serum ferritin (51.5%vs 14.6%, p < 0.001 for trend) and a higher prevalence of family history of DM (48.5%vs 18.8%, p = 0.004). In the multivariate analysis, persistently-elevated serum ferritin (OR, 10.66; 95% CI, 1.95-58.19, p = 0.006) and family history of DM (OR, 4.82; 95% CI, 1.34-17.33, p = 0.016) remained significantly associated with the presence of GMA. Conclusion: GMA are highly prevalent in patients with PCT and mostly develop a long time after the diagnosis of PCT. Persistent hyperferritinemia seems to be a risk biomarker of GMA in PCT patients, probably in the setting of chronic iron overload and hepatic inflammation. Strict long-term monitoring of glucose metabolism and serum ferritin may be advisable in the routine follow-up of PCT patients. |
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Authors:
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C Muñoz-Santos; A Guilabert; N Moreno; M Gimenez; E Darwich; J To-Figueras; C Herrero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-12 |
Journal Detail:
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Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 British Association of Dermatologists. |
Affiliation:
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Department of Dermatology Department of Endocrinology and Diabetes Unit Department of Biochemistry and Molecular Genetics, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain Institut Català de la Salut, SAP Santa Coloma de Gramenet, Barcelona, Spain. |
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