Document Detail

Association between the -634C/G polymorphisms of the vascular endothelial growth factor and retinopathy in type 2 diabetes: a meta-analysis.
MedLine Citation:
PMID:  20591524     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate the association of vascular endothelial growth factor (VEGF) -634C/G polymorphism with retinopathy in type 2 diabetes.
METHODS: 8 studies with 1183 cases and 1057 controls were included. Allelic and genotypic comparisons between cases and controls were evaluated.
RESULTS: Our meta-analysis did not suggest a significant association of the -634C/G polymorphism with diabetic retinopathy (DR) and proliferative diabetic retinopathy (PDR) (P>0.05). The pooled odds ratios (ORs) for allelic frequency comparison, recessive model comparison, dominant model comparison, and additive model showed that the -634C/G polymorphism is significantly associated with nonproliferative diabetic retinopathy (NPDR): OR=1.61 [95% confidence interval (CI, 1.23, 2.10)], P=0.0005, P(heterogeneity)=0.38, OR=2.24 [95% CI (1.15, 4.39)], P=0.02, P(heterogeneity)=0.24, OR=1.87 [95% CI (1.01, 3.48)], P=0.05, P(heterogeneity)=0.16, and OR=2.91 [95% CI (1.33, 6.39)], P=0.008, P(heterogeneity)=0.26, respectively. However, in sensitivity analyses, we only detected a marginally significant association of the C allele with NPDR: OR=1.54 [95% CI (1.00, 2.39)], P=0.05, P(heterogeneity)=0.17.
CONCLUSIONS: Our meta-analysis does not support the association of the VEGF -634C/G polymorphism with DR and PDR. Significant association between this polymorphism and NPDR was detected in this meta-analysis. However, this association is not robust and could be due to chance.
Tongfeng Zhao; Jiangpei Zhao
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2010-06-29
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  90     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  45-53     Citation Subset:  IM    
Department of Geriatrics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Number 88, Hangzhou, Zhejiang, PR China.
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MeSH Terms
5' Untranslated Regions / genetics
Diabetes Mellitus, Type 2 / complications*
Diabetic Retinopathy / genetics*
Genetic Association Studies
Models, Genetic
Polymorphism, Single Nucleotide*
Vascular Endothelial Growth Factor A / genetics*
Reg. No./Substance:
0/5' Untranslated Regions; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A

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