| Association between the -634C/G polymorphisms of the vascular endothelial growth factor and retinopathy in type 2 diabetes: a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 20591524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To investigate the association of vascular endothelial growth factor (VEGF) -634C/G polymorphism with retinopathy in type 2 diabetes. METHODS: 8 studies with 1183 cases and 1057 controls were included. Allelic and genotypic comparisons between cases and controls were evaluated. RESULTS: Our meta-analysis did not suggest a significant association of the -634C/G polymorphism with diabetic retinopathy (DR) and proliferative diabetic retinopathy (PDR) (P>0.05). The pooled odds ratios (ORs) for allelic frequency comparison, recessive model comparison, dominant model comparison, and additive model showed that the -634C/G polymorphism is significantly associated with nonproliferative diabetic retinopathy (NPDR): OR=1.61 [95% confidence interval (CI, 1.23, 2.10)], P=0.0005, P(heterogeneity)=0.38, OR=2.24 [95% CI (1.15, 4.39)], P=0.02, P(heterogeneity)=0.24, OR=1.87 [95% CI (1.01, 3.48)], P=0.05, P(heterogeneity)=0.16, and OR=2.91 [95% CI (1.33, 6.39)], P=0.008, P(heterogeneity)=0.26, respectively. However, in sensitivity analyses, we only detected a marginally significant association of the C allele with NPDR: OR=1.54 [95% CI (1.00, 2.39)], P=0.05, P(heterogeneity)=0.17. CONCLUSIONS: Our meta-analysis does not support the association of the VEGF -634C/G polymorphism with DR and PDR. Significant association between this polymorphism and NPDR was detected in this meta-analysis. However, this association is not robust and could be due to chance. |
| | |
Authors:
|
Tongfeng Zhao; Jiangpei Zhao |
Related Documents
:
|
18458324 - Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney comp... 12698304 - Differences in flurbiprofen pharmacokinetics between cyp2c9*1/*1, *1/*2, and *1/*3 geno... 19622614 - Hhex-ide polymorphism is associated with low birth weight in offspring with a family hi... 18855224 - Association of c34t ampd1 gene polymorphism with features of metabolic syndrome in pati... 1640854 - The effect of epinephrine on glucose-mediated and insulin-mediated glucose disposal in ... 19170834 - The effects of hypoestrogenism on the vaginal wall: interference with the normal sexual... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2010-06-29 |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: 90 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-06 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
|
Languages: eng Pagination: 45-53 Citation Subset: IM |
Affiliation:
|
Department of Geriatrics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Number 88, Hangzhou, Zhejiang, PR China. zhaotongfeng@yahoo.com.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
5' Untranslated Regions
/
genetics Diabetes Mellitus, Type 2 / complications* Diabetic Retinopathy / genetics* Genetic Association Studies Humans Models, Genetic Polymorphism, Single Nucleotide* Vascular Endothelial Growth Factor A / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/5' Untranslated Regions; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of agouti-related peptide levels in peripheral blood of postpartum pre-eclamptic and non ...
Next Document: Clinical and genetic analysis of the insulin receptor gene in a Chinese patient with extreme insulin...