Document Detail


Association between polymorphisms in serotonin transporter gene and attention deficit hyperactivity disorder in Chinese Han subjects.
MedLine Citation:
PMID:  16941663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior work has shown reduced serotonin transmission to be associated with impulsivity and behavioral problems. The current study assessed the association between ADHD and two variants of the serotonin transporter gene: the 44-bp deletion/insertion polymorphism (5-HTTLPR) and the 17 bp-repeat polymorphism in intron 2 (STin2.VNTR). We hypothesized that ADHD phenotypes associated with impulsivity would show an association with these variants. Two-hundred and ninety-three ADHD trios were genotyped and analyzed using transmission disequilibrium test (TDT) analysis and haplotype analysis. We found no association between the STin2.VNTR and ADHD, but did find preferential transmission of the S allele of the 5-HTTLPR polymorphism (chi(2) = 5.751, P = 0.016) to probands with ADHD. Haplotype analysis found the L/10 haplotype was over-transmitted (chi(2) = 6.172, P = 0.013), while L/12 was under-transmitted to probands with ADHD (chi(2) = 4.866, P = 0.027).
Authors:
Jun Li; Yufeng Wang; Rulun Zhou; Haobo Zhang; Li Yang; Bing Wang; Stephen V Faraone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics     Volume:  144B     ISSN:  1552-4841     ISO Abbreviation:  Am. J. Med. Genet. B Neuropsychiatr. Genet.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-27     Completed Date:  2007-02-27     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101235742     Medline TA:  Am J Med Genet B Neuropsychiatr Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-9     Citation Subset:  IM    
Affiliation:
Institute of Mental Health, Peking University, Peking University Sixth Hospital, Beijing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Asian Continental Ancestry Group / genetics*
Attention Deficit Disorder with Hyperactivity / classification,  genetics*,  metabolism
Base Sequence
Child
China
DNA / genetics
Female
Gene Frequency
Genotype
Haplotypes
Humans
Introns
Male
Minisatellite Repeats
Phenotype
Polymorphism, Genetic*
Receptors, Serotonin / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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