Document Detail

Association between polymorphisms in renin-angiotensin system genes and primary ovarian insufficiency in Korean women.
MedLine Citation:
PMID:  23615648     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: The purpose of this study was to evaluate the relationship between angiotensin-converting enzyme (ACE; insertion/deletion), angiotensinogen (AGT M235T), and angiotensin II type 1 receptor (AT1R 1166A>C) and the prevalence of primary ovarian insufficiency (POI) in Korean women.
METHODS: A total of 133 women with POI and 238 controls were genotyped for polymorphic sites in each gene using polymerase chain reaction-restriction fragment length polymorphism analysis.
RESULTS: ACE ID and ID + II variants occurred more frequently in women with POI than in controls (odds ratio [OR], 1.830; 95% CI, 1.040-3.221; P = 0.040; and OR, 1.797; 95% CI, 1.055-3.060; P = 0.031, respectively). The AT1R 1166AC genotype occurred more frequently in participants with POI than in controls (OR, 3.171; 95% CI, 1.562-6.436; P = 0.002). Comparing the combined genotype frequencies of ACE/AT1R revealed that the frequencies of ID/AA, ID/AC, and II/AC were higher in participants than in controls (OR, 1.916; 95% CI, 1.053-3.485; P = 0.043; OR, 3.544; 95% CI, 1.207-10.407; P = 0.036; and OR, 7.875; 95% CI, 2.224-27.881; P = 0.001, respectively). The TT/AC genotype for combined genotyping of AGT/AT1R was more frequently observed in the POI group than in the control group (OR, 3.472; 95% CI, 1.450-8.313; P = 0.006). In multifactor dimensionality reduction-based haplotype analysis, the I-T-C genotype of ACE/AGT/AT1R was a possible predisposing factor for POI (OR, 4.678; 95% CI, 1.721-12.717; P = 0.002).
CONCLUSIONS: This study demonstrates that polymorphisms in the renin-angiotensin system are related to the prevalence of POI. Thus, these renin-angiotensin system genes may serve as a novel marker for predicting the development of POI.
Yong Wook Jung; Young Joo Jeon; Hye Mi Park; Bo Eun Lee; Hyungchul Rah; Woo Sik Lee; Tae Ki Yoon; Nam Keun Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  20     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-7     Citation Subset:  IM    
From the 1Department of Obstetrics and Gynecology, School of Medicine, 2Department of Biomedical Science, College of Life Science, and 3Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; and 4Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, South Korea.
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