| Association between polymorphisms in the TNF region and systemic lupus erythematosus in the Italian population. | |
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MedLine Citation:
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PMID: 8813745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this work was to the hypothesis that MHC encoded susceptibility factors for SLE lie in the TNF region. An association study was performed by analyzing 123 northern Italian SLE patients and 199 matched controls for three TNF markers: two polymorphisms in the TNFA promoter and the TNFa microsatellite. Haplotypic combinations of TNF markers were also compared in patients and controls. No significant association was observed considering either the whole SLE panel or SLE clinical and immunological subtypes. Three TNF-238/A homozygous patients were detected, while no homozygote was present in controls. The clinical and immunological phenotype of the three -238/A homozygotes suggests that the -238/AA genotype is a marker of a particular clinical subtype. |
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Authors:
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S D'Alfonso; G Colombo; S Della Bella; R Scorza; P Momigliano-Richiardi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tissue antigens Volume: 47 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-12-04 Completed Date: 1996-12-04 Revised Date: 2012-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: DENMARK |
Other Details:
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Languages: eng Pagination: 551-5 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Mediche, Novara, Universita' di Torino, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Genetic Predisposition to Disease Humans Italy Lupus Erythematosus, Systemic / genetics* Major Histocompatibility Complex / genetics Polymorphism, Genetic* Polymorphism, Restriction Fragment Length Tumor Necrosis Factor-alpha / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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E.0162//Telethon |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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