Document Detail


Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD.
MedLine Citation:
PMID:  23276910     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative stress may play a role in the pathogenesis of age-related macular degeneration (AMD). In this study we examined the association between AMD risk and polymorphisms of genes encoding enzymes involved in the generation and removal of iron-mediated oxidation: NQO1 (609C> T, rs1800566), NOS3 (894G>T, rs1799983) and NFE2L2 (28312647A>G, rs6726395). We found that the G/G genotype of the rs6726395 polymorphism was associated with a decreased risk of AMD wet form (OR 0.44) and on the other hand the T allele of the rs1799983 polymorphism increased such risk (OR 1.63). We also observed that the C/C-G/T combined genotype of the rs1800566 and rs1799983 polymorphisms was positively correlated with a reduced risk of AMD as well as of its dry form (OR 0.40 and 0.35). The presence of the G/T-G/G combined genotype of the rs1799983 and rs6726395 polymorphisms decreased the risk of this disease (OR 0.35). The results obtained in our study suggest a potential role of the rs1800566, rs1799983 and rs6726395 polymorphisms in the AMD pathogenesis.
Authors:
Ewelina Synowiec; Tomasz Sliwinski; Katarzyna Danisz; Janusz Blasiak; Anna Sklodowska; Dorota Romaniuk; Cezary Watala; Jerzy Szaflik; Jacek P Szaflik
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-90     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Medical University of Warsaw and Samodzielny Publiczny Kliniczny Szpital Okulistyczny, Sierakowskiego 13, 03-709 Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Genetic Predisposition to Disease
Humans
Macular Degeneration / genetics*
Male
Middle Aged
NAD(P)H Dehydrogenase (Quinone) / genetics*
NF-E2-Related Factor 2 / genetics*
Nitric Oxide Synthase Type III / genetics*
Oxidative Stress / genetics
Risk
Risk Factors
Chemical
Reg. No./Substance:
0/NF-E2-Related Factor 2; 0/NFE2L2 protein, human; EC 1.14.13.39/NOS3 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2/NQO1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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