| Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia. | |
| | |
MedLine Citation:
|
PMID: 22836153 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Elevated plasma homocysteine level has emerged as a relatively newly recognised risk factor for coronary artery disease (CAD). However, reduction of plasma homocysteine levels in large prospective studies did not appear to reduce the risk for subsequent cardiac events. In this study, we investigated the association between plasma homocysteine levels and quantitative indices of myocardial perfusion SPECT imaging in patients referred for myocardial ischaemia. METHODS: Quantitative myocardial perfusion SPECT indices were obtained for 120 patients who were recruited for the study. All patients underwent a two-day rest-stress myocardial perfusion imaging. Plasma venous sampling was done on all patients after an overnight fast. Of the 120 participants (mean age 56 years, 53% males), 33% had elevated plasma homocysteine levels. The plasma homocysteine level was then compared to the results of imaging and other known risk factors. RESULTS: After adjustment for traditional risk factors of coronary artery disease, patients with elevated homocysteine levels had a significantly higher mean summed stress score (SSS) (11.3 vs 6.9, p = 0.02) than patients with a normal homocysteine level. This was true for both single- and multivessel disease. Also, patients with elevated homocysteine levels had a higher stress end-systolic volume (SESV) (137 vs 105 ml, p = 0.03) and lower post-stress left ventricular ejection fraction (SEF) (54 vs 64%, p = 0.02). The patients with elevated plasma homocysteine levels also had a significantly lower mean body mass index (BMI) (26.6 vs 30.6 kg/m(2), p = 0.002). There was a significant relationship between the total number of known risk factors in a patient with CAD and the proportion of patients presenting with elevated plasma homocysteine levels (p = 0.03). Also, the extent of infarct, as measured by the summed rest score (SRS), was more closely correlated with an elevated homocysteine level than with the degree of ischaemia. CONCLUSION: There was a correlation between plasma homocysteine level and the presence and extent of myocardial perfusion abnormalities in patients with established coronary artery disease, in particular those with multiple risk factors and multi-vessel infarction. |
| | |
Authors:
|
A Ankrah; J Buscombe; M M Sathekge |
Related Documents
:
|
22194403 - Hypertrophic cardiomyopathy: a real risk factor for stroke. 22350693 - The potential utility of (123)i-mibg in atrial fibrillation and in the electrophysiolog... 12563143 - Coronary calcification compared in patients with acute versus in those with chronic cor... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cardiovascular journal of Africa Volume: 23 ISSN: 1995-1892 ISO Abbreviation: Cardiovasc J Afr Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101313864 Medline TA: Cardiovasc J Afr Country: South Africa |
Other Details:
|
Languages: eng Pagination: 313-7 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, University of Pretoria and Steve Biko Academic Hospital, Pretoria, South Africa. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prevalence of cardiovascular risk factors in an urban area of Togo: a WHO STEPS-wise approach in Lom...
Next Document: A prospective review of acute coronary syndromes in an urban hospital in sub-Saharan Africa.