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Association between placental mineral deposition, villous architecture and fetal aneuploidy.
MedLine Citation:
PMID:  21126116     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
We retrospectively evaluated the relationship between fetal aneuploidy and placental mineral deposits and villous architecture in 2nd trimester placentas of mid-trimester pregnancy terminations for fetal anomaly. Study cases were aneuploid and matched with euploid controls. Six slides per case were histologically evaluated. Our findings showed significantly increased subtrophoblastic mineral depositions in aneuploidy placentas; also, villous architecture changes between study and control cases were significant for multifocal/extensive villous scalloping and syncytial budding. Our conclusion was that placental histological findings of extensive subtrophoblastic mineral deposition, multifocal/extensive villous scalloping and syncytial budding may suggest aneuploidy.
Authors:
R Khan; M Sanders; L Ernst; J Egan; W Campbell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  30     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  800-3     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, South Mead Hospital, Bristol, UK. rahila.khan1@ntlworld.com
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