Document Detail


Association between periodontal pathogens and risk of nonfatal myocardial infarction.
MedLine Citation:
PMID:  21375559     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Andriankaja O, Trevisan M, Falkner K, Dorn J, Hovey K, Sarikonda S, Mendoza T, Genco R. Association between periodontal pathogens and risk of nonfatal myocardial infarction. Community Dent Oral Epidemiol 2011; 39: 177-185. © 2011 John Wiley & Sons A/S Abstract -  Background:  The direct effect of periodontal pathogens on atherosclerotic plaque development has been suggested as a potential mechanism for the observed association between periodontal disease and coronary heart disease, but few studies have tested this theory. Objectives:  (i) To assess the association of periodontal pathogens in periodontal pockets with the risk of myocardial infarction (MI) and (ii) to assess whether an increase in the number of periodontal bacterial species increases the risk of MI. Methods:  A total of 313 cases and 747 controls, consisting of Caucasian men and women from Western New York, aged 35 to 69 years, were recruited for this study. The presence of microorganisms was assessed by indirect immunofluorescence microscopy, using species-specific polyclonal and monoclonal serodiagnostic reagents. The presence of six periodontal pathogens, Porphyromonas gingivalis (Pg), Tannerella forsythensis (Tf), Prevotella intermedia (Pi), Campylobacter recta (Cr), Fusobacterium nucleatum (Fn), and Eubacterium saburreum (Es), and their co-occurrence (0-6) was compared with the odds of having myocardial infarction. Results:  Univariate analyses revealed a higher percentage of the presence of each bacterium in cases compared to controls. In multivariate analyses, only Tf and Pi were statistically associated with an increase in the odds of having MI [Odds ratio OR = 1.62; 95% CI (1.18-2.22); and 1.40; 95% (1.02-1.92), respectively] after adjusting for age, gender, education, cholesterol, high blood pressure, diabetes, and total pack-years of cigarette smoking. An increase in the number of different periodontal bacteria in pockets was also found to increase the odds of MI [adjusted OR = 1.14; 95% CI (1.03-1.26)]. Participants who had three species or more of periodontal pathogens had about 2-fold increase in odds of having nonfatal MI than those who did not have any type of bacterial species [OR = 2.01 (1.31-3.08)]. Conclusion:  The presence of periodontal pathogens, specifically Tf or Pi, and an increase in total burden of periodontal pathogenic species were both associated with increased odds of having MI. However, further studies are needed to better assess any causal relationship, as well as the biological mechanisms underlying this association.
Authors:
Oelisoa Andriankaja; Maurizio Trevisan; Karen Falkner; Joan Dorn; Kathleen Hovey; Sreenivasa Sarikonda; Tania Mendoza; Robert Genco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Community dentistry and oral epidemiology     Volume:  39     ISSN:  1600-0528     ISO Abbreviation:  Community Dent Oral Epidemiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410263     Medline TA:  Community Dent Oral Epidemiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  177-85     Citation Subset:  D; IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
University of Puerto Rico, Center for Clinical Research and Health Promotion Nevada System of Higher Education, Health Sciences System University at Buffalo, Social and Preventive Medicine University at Buffalo, School of Dental Medicine, Oral Biology University at Buffalo, Department of Exercise and Nutrition Sciences University of North Carolina at Chapel Hill, Go Health Center, USA.
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