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Association between perfluorinated compounds and time to pregnancy in a prospective cohort of Danish couples attempting to conceive.
MedLine Citation:
PMID:  22246448     Owner:  NLM     Status:  Publisher    
BACKGROUNDPerfluorinated chemicals (PFCs) have been widely used and have emerged as important food contaminants. A recent study on pregnant women suggested that PFC exposure was associated with a longer time to pregnancy (TTP). We examined the association between serum concentrations of PFCs in females and TTP in 222 Danish first-time pregnancy planners during the years 1992-1995.METHODSThe couples were enrolled in the study when discontinuing birth control and followed for six menstrual cycles or until a clinically recognized pregnancy occurred. Fecundability ratio (FR) was calculated using discrete-time survival models. In addition, odds ratio (OR) for TTP >6 cycles was calculated.RESULTSOR for TTP >6 cycles for those with PFC concentrations above the median were 0.96 [95% confidence interval (CI): 0.54-1.64] for perfluorooctane sulfonic acid (PFOS), the major PFC, compared with those below the median. FRs for those with PFOS concentrations above the median were 1.05 (95% CI: 0.74-1.48) compared with those below the median. Other PFCs showed the same lack of association with TTP. The results were not affected by adjustment for covariates. PFOS and perfluorooctanoic acid concentrations were similar to those observed in a previous Danish study.CONCLUSIONSThese findings suggest that exposure to PFCs affects TTP only to a small extent, if at all.
Sonja Vestergaard; Flemming Nielsen; Anne-Maria Andersson; Niels Henrik Hjøllund; Philippe Grandjean; Helle Raun Andersen; Tina Kold Jensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-13
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  -     ISSN:  1460-2350     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, J.B. Winsloews Vej 17A, DK-5000 Odense C, Denmark.
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