Document Detail

Association between paroxysmal tonic spasms and neuromyelitis optica.
MedLine Citation:
PMID:  22232353     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To determine the frequency of the association between tonic spasms and neuromyelitis optica (NMO) at our center.
DESIGN: An institutional review board-approved retrospective study of clinical, serological, and radiographic characteristics of patients with NMO.
SETTING: Multiple sclerosis center. Patients  Patients with NMO treated at our center between 1990 and 2008. Main Outcome Measure  Records were examined for documentation of tonic spasms.
RESULTS: Of 110 patients with International Classification of Diseases code 341, 57 patients met diagnostic criteria for NMO. Of these, 8 patients (14%) had documented typical tonic spasms (median age at onset, 39.5 years; range, 13.8-54.2 years). Of those patients, 4 were African American, 3 were Hispanic, and 1 was white. Only 1 was male. The NMO-IgG antibody was found in 1 of 6 patients tested. Tonic spasms appeared after a mean of 24.6 months (range, 0-91 months). In 2 of 57 patients meeting NMO criteria, tonic spasms accompanied their initial episodes. Seven of 8 patients who had tonic spasms responded to treatment with carbamazepine within 1 week.
CONCLUSION: Tonic spasms are associated with NMO more commonly than with multiple sclerosis and may be a presenting sign in both diseases.
Nida Usmani; Gurdesh Bedi; Byron L Lam; William A Sheremata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  69     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  AIM; IM    
Multiple Sclerosis Center, Department of Neurology, Miller School of Medicine, University of Miami, NPF Bldg, 1501 NW 9th Ave, Miami, FL 33136.
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