| Association between oxidative stress parameters and inflammation markers according to the gravity of the acute coronary syndrome. | |
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MedLine Citation:
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PMID: 21780037 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Cardiovascular disease is the consequence of appearance and development of atherosclerosis lesions of associated with a inflammatory complication. Aim: To elucidate a possible association between several inflammation and oxidative stress markers according to the severity of coronary artery disease. Methods: This study was carried on 93 coronary subjects with: unstable angina (UA; n=42); stable angina (SA; n=15) and acute myocardial infarction (AMI; n=36) and 140 control subjects to whom lipidic, oxidative and inflammatory parameters were determined. Results: In addition to a moderate hyperhomocysteinemia observed in the coronary artery disease, a significant higher levels of the oxidized LDL (ox-LDL) were found among these patients (p< 0.001). A positive correlation was found between the markers of the inflammation and the gravity of the acute coronary syndrome. One note a significant increase of the rate of ox-LDL and high sensitive CRP to AMI by reports in UA and SA (p=0.00, and p=0.001 respectively) which is linked to an elevation of the plasmatic concentration of the total homocysteine. Conclusion: This study suggests an association between the markers of the inflammation and oxidative parameters in the acute coronary syndrome. |
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Authors:
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Amel Nakbi; Nadia Koubaa; Khaldoun Ben Hamda; Sonia Hammami; Nabil Attia; Radhia Boumiza; Abdelhedi Miled; Mohamed Ben Farhat; Mohamed Hammami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: La Tunisie médicale Volume: 89 ISSN: 0041-4131 ISO Abbreviation: Tunis Med Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413766 Medline TA: Tunis Med Country: Tunisia |
Other Details:
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Languages: eng Pagination: 621-6 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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