Document Detail

Association between oxidative stress in pregnancy and preterm premature rupture of membranes.
MedLine Citation:
PMID:  17442295     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Premature rupture of membranes (PROM) is caused by collagen damage in the chorioamniotic sac leading to tearing. Reactive oxygen species (ROS) may be the cause of collagen damage. Isoprostanes (F(2)-IP) are produced by ROS attack on polyunsaturated fatty acids and are sensitive and specific biomarkers of lipid-peroxidation in vivo. AIM: To verify whether oxidative stress occurs in pregnancies associated with preterm PROM. METHODS: F(2)-IPs were measured in amniotic fluid of 16 pregnancies with preterm PROM (Group II) and 97 without PROM (Group I). RESULTS: F(2)-IP concentrations (pg/mL) were significantly higher in group II than group I (p<0.0001). The ROC curve showed a sensitivity of 100% and a specificity of 84.5% at a cut-off of 124.4 pg/mL. CONCLUSIONS: An association exists between oxidative stress in pregnancy and preterm PROM. The detection of amniotic fluid F(2)-IP concentrations seems to be a reliable predictive index of risk of preterm PROM.
Mariangela Longini; Serafina Perrone; Piero Vezzosi; Barbara Marzocchi; Antonio Kenanidis; Giovanni Centini; Lucia Rosignoli; Giuseppe Buonocore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-20
Journal Detail:
Title:  Clinical biochemistry     Volume:  40     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-29     Completed Date:  2007-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  793-7     Citation Subset:  IM    
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, V le Bracci 36, Siena, Italy.
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MeSH Terms
Amniotic Fluid / metabolism
F2-Isoprostanes / metabolism
Fetal Membranes, Premature Rupture / metabolism*,  pathology
Infant, Newborn
Oxidative Stress*
Reg. No./Substance:

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