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Association between organic dietary choice during pregnancy and hypospadias in offspring: A study of mothers of 306 boys operated for hypospadias.
MedLine Citation:
PMID:  23036983     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The etiology of hypospadias is poorly understood. Exposure to pesticides has been considered a risk factor, although the results are inconsistent. A significant exposure route to pesticides is through diet, and pesticide residues are more frequently reported in conventional than organic food products. This study aims to examine the association between organic dietary choice during pregnancy and hypospadias in the offspring. MATERIALS AND METHODS: Mothers of boys operated for hypospadias (306) were frequency matched on geography and child birth year to 306 mothers of healthy boys in a case-control study. Telephone interviews on demographic and lifestyle factors including intake and organic choice of selected food items (milk, dairy products, egg, fruit, vegetables and meat) were conducted. Logistic regression models were constructed for diet variables and odds ratios were calculated controlling for maternal age, BMI and alcohol consumption. RESULTS: Overall organic choice of food items during pregnancy were not associated with hypospadias in the offspring. However, frequent current consumption of high fat dairy products (milk butter) while rarely or never choosing the organic alternative to these products during pregnancy was associated with increased odds of hypospadias (adjusted OR=2.18, 95% CI [1.09-4.36]). CONCLUSION: This large case-control study of boys operated for hypospadias found a suggestive association between not chosing the organic alternative and having a high current intake of non-organic butter and cheese and hypospadias in the offspring.This could be due to chemical contamination of high fat dairy products. However, general lifestyle and health behavior related to choosing organic alternative may also explain the findings.
Authors:
Jeppe Schultz Christensen; Camilla Asklund; Niels E Skakkebæk; Niels Jørgensen; Helle Raun Andersen; Troels Munch Jørgensen; Lars Henning Olsen; Anette Pernille Høyer; Jan Moesgaard; Jørgen Thorup; Tina Kold Jensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
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