Document Detail

Association between neuropsychiatric and autonomic dysfunction in Alzheimer's disease.
MedLine Citation:
PMID:  12102448     Owner:  NLM     Status:  MEDLINE    
We sought to determine whether there was an association between specific neuropsychiatric deficits and autonomic dysfunction in patients with Alzheimer's disease (AD). We studied 20 patients and 20 age-matched control subjects with neuropsychiatric tests (Blessed, Cornell depression and NPI scores) and autonomic tests (Deep breath (HRdb), 30:15 ratio and orthostatic hypotension (Bpoh)). The 30:15 ratio was consistently reduced in AD patients as compared to control subjects (1.05+/-0.07 for patients and 1.18+/-0.1 for controls, p 0.001). Whereas there were no significant differences in the HRdb and presence of Bpoh. In AD patients with an abnormal 30:15 ratio, there were significant abnormalities in the Blessed score and in the apathy, delusions and aberrant motor behavior items of the NPI. The other autonomic tests did not correlate with any neuropsychiatric score. The relationship between abnormal cortical function and impaired 30:15 ratio suggested that a lack of cortical modulation of autonomic circuits may underlie cardiovascular instability in these patients.
Juan Idiaquez; Eduardo Sandoval; Alejandra Seguel
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  12     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-07-09     Completed Date:  2002-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Universidad de Valparaíso, Chile.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / physiopathology*,  psychology*
Autonomic Nervous System / physiopathology*
Blood Pressure / physiology
Heart Rate / physiology
Middle Aged
Neuropsychological Tests
Respiratory Mechanics / physiology

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