Document Detail

Association between nasal carriage of Staphylococcus aureus and the human complement cascade activator serine protease C1 inhibitor (C1INH) valine vs. methionine polymorphism at amino acid position 480.
MedLine Citation:
PMID:  17498209     Owner:  NLM     Status:  MEDLINE    
Staphylococcus aureus produces compounds that interfere with complement deposition. We hypothesized that humans have developed countermeasures to staphylococcal complement evasion and we screened for single nucleotide polymorphisms in the serine protease C1 inhibitor (C1INH) gene at amino acid position 480 (valine vs. methionine) and nasal carriage of S. aureus. In our study cohort, 38 individuals were persistently colonized by S. aureus, whereas 50 were invariably culture-negative. A trend was observed towards an increased prevalence of the Val/Val genotype in noncarriers compared to persistent carriers (OR 0.50, P=0.07). The Val/Val genotype was significantly overrepresented in noncarriers compared to 463 Caucasian blood donors (OR 0.52, P=0.02). These findings suggest that susceptibility to S. aureus nasal carriage is associated with the C1INH V480M polymorphism.
Marieke Emonts; Christa E de Jongh; Jeanine J Houwing-Duistermaat; Willem B van Leeuwen; Ronald de Groot; Henri A Verbrugh; Peter W M Hermans; Alex van Belkum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-10
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  50     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  330-2     Citation Subset:  IM    
Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Amino Acid Sequence
Amino Acid Substitution
Carrier State
Complement C1 Inactivator Proteins / genetics*
Genetic Predisposition to Disease*
Methionine / chemistry,  genetics
Middle Aged
Molecular Sequence Data
Nose / microbiology
Polymorphism, Genetic*
Serpins / genetics*
Staphylococcal Infections / genetics*
Staphylococcus aureus*
Valine / chemistry,  genetics
Reg. No./Substance:
0/Complement C1 Inactivator Proteins; 0/SERPING1 protein, human; 0/Serpins; 63-68-3/Methionine; 7004-03-7/Valine

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