Association between nasal carriage of Staphylococcus aureus and the human complement cascade activator serine protease C1 inhibitor (C1INH) valine vs. methionine polymorphism at amino acid position 480. | |
MedLine Citation:
|
PMID: 17498209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Staphylococcus aureus produces compounds that interfere with complement deposition. We hypothesized that humans have developed countermeasures to staphylococcal complement evasion and we screened for single nucleotide polymorphisms in the serine protease C1 inhibitor (C1INH) gene at amino acid position 480 (valine vs. methionine) and nasal carriage of S. aureus. In our study cohort, 38 individuals were persistently colonized by S. aureus, whereas 50 were invariably culture-negative. A trend was observed towards an increased prevalence of the Val/Val genotype in noncarriers compared to persistent carriers (OR 0.50, P=0.07). The Val/Val genotype was significantly overrepresented in noncarriers compared to 463 Caucasian blood donors (OR 0.52, P=0.02). These findings suggest that susceptibility to S. aureus nasal carriage is associated with the C1INH V480M polymorphism. |
Authors:
|
Marieke Emonts; Christa E de Jongh; Jeanine J Houwing-Duistermaat; Willem B van Leeuwen; Ronald de Groot; Henri A Verbrugh; Peter W M Hermans; Alex van Belkum |
Related Documents
:
|
7909529 - A sau3a polymorphism in the 5' end of the it15 gene that nonrandomly segregates with th... 1478649 - Cloning and linkage mapping of three polymorphic tetranucleotide (taaa)n repeats on hum... 11961419 - Voiceless consonants and locus equations: a comparison with electropalatographic data o... 15820309 - Distribution of human beta-defensin polymorphisms in various control and cystic fibrosi... 1979059 - Linkage mapping of the highly informative dna marker d21s156 to human chromosome 21 usi... 1211669 - Retina-specific ldh isozyme in blueback herring, alosa aestivalis (mitchell), and alewi... 8291549 - Familial occurrence of agonadism and multiple internal malformations in phenotypically ... 10511559 - Developmental genetics of the essential drosophila nucleoporin nup154: allelic differen... 16467359 - Sfrp1 and sfrp2 regulate anteroposterior axis elongation and somite segmentation during... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-10 |
Journal Detail:
|
Title: FEMS immunology and medical microbiology Volume: 50 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-26 Completed Date: 2007-09-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: England |
Other Details:
|
Languages: eng Pagination: 330-2 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Amino Acid Sequence Amino Acid Substitution Carrier State Complement C1 Inactivator Proteins / genetics* Female Genetic Predisposition to Disease* Humans Male Methionine / chemistry, genetics Middle Aged Molecular Sequence Data Nose / microbiology Polymorphism, Genetic* Serpins / genetics* Staphylococcal Infections / genetics* Staphylococcus aureus* Valine / chemistry, genetics |
Chemical | |
Reg. No./Substance:
|
0/Complement C1 Inactivator Proteins; 0/SERPING1 protein, human; 0/Serpins; 63-68-3/Methionine; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caveolin-1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial ce...
Next Document: Effect of antibiotics on the bacterial population of the rabbit caecum.