Document Detail

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease.
MedLine Citation:
PMID:  23830313     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The n-3 polyunsaturated fatty acids are dietary components derived from fish oil with beneficial cardiovascular effects that may relate in part to anti-inflammatory properties. Peripheral artery disease (PAD) is characterized by a marked proinflammatory state. We hypothesized that the n-3 polyunsaturated fatty acids content of red blood cells (omega-3 index) would be correlated with biomarkers of inflammation and vascular function in a PAD cohort.
METHODS: This was a cross-sectional study of subjects who presented to an outpatient vascular surgery clinic for evaluation of PAD. We used linear regression to evaluate the independent association between the omega-3 index, inflammatory biomarkers (C-reactive protein [CRP], intercellular adhesion molecule-1, interleukin-6, and tumor-necrosis-factor-α) and endothelial function (brachial artery flow mediated dilation).
RESULTS: 64 subjects (61 claudicants and three with critical limb ischemia) were recruited for the study. The mean CRP level was 5.0 ± 5.0 mg/L, and the mean omega-3 index was 5.0% ± 1.8%. In an unadjusted model, the omega-3 index was negatively associated with CRP (38% increase in CRP for one standard deviation decrease in the omega-3 index; P = .007), which remained significant after adjustment for age, body mass index, smoking, ankle-brachial index, and high-density lipoprotein (33%; P = .04). There was also evidence for independent associations between the omega-3 index and IL-6 (P = .001). There were no significant associations between the omega-3 index and vascular function tests.
CONCLUSIONS: In a cohort of patients with PAD, the omega-3 index was inversely associated with biomarkers of inflammation even after adjustment for covariates including the ankle-brachial index. Because patients with PAD have a high inflammatory burden, further studies should be conducted to determine if manipulation of omega-3 index via dietary changes or fish oil supplementation could improve inflammation and symptoms in these patients.
S Marlene Grenon; Michael S Conte; Emily Nosova; Hugh Alley; Karen Chong; William S Harris; Eric Vittinghoff; Christopher D Owens
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-07-02
Journal Detail:
Title:  Journal of vascular surgery     Volume:  58     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-28     Completed Date:  2014-01-21     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1283-90     Citation Subset:  IM    
Copyright Information:
Published by Mosby, Inc.
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MeSH Terms
Ankle Brachial Index
Biological Markers / blood
Brachial Artery / metabolism,  physiopathology
C-Reactive Protein / analysis*
Cross-Sectional Studies
Endothelium, Vascular / metabolism,  physiopathology
Erythrocytes / chemistry*
Fatty Acids, Omega-3 / blood*
Inflammation Mediators / blood*
Linear Models
Logistic Models
Middle Aged
Peripheral Arterial Disease / blood*,  diagnosis,  immunology,  physiopathology
Predictive Value of Tests
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Inflammation Mediators; 9007-41-4/C-Reactive Protein

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