Document Detail

Association between myasthaenia gravis and systemic lupus erythematosus: three case reports and review of the literature.
MedLine Citation:
PMID:  21722072     Owner:  NLM     Status:  MEDLINE    
The coexistence of systemic lupus erythematosus (SLE) and myasthaenia gravis (MG) has been reported previously. Because of their shared clinical characteristics and autoantibody-mediated pathogenesis, an SLE expert panel decided to include MG as one of the 19 neuropsychiatric SLE syndromes. This study reports a cluster of three cases of SLE/MG overlap from our cohort and a review of the published data concerning this overlap of SLE and MG. A systematic Medline review revealed 13 cases described in eight publications from 1994 to 2009. In summary, 12 of the 16 patients (three from our cohort and 13 from the reported cases) were women with an average age of 34 years. The most common SLE manifestations were polyarthritis (15 out of 16 patients), skin rashes (5/16), serositis (5/16), and cytopaenias (10/16). All of the patients were anti-nuclear antibodies (ANA) positive and 15/16 were anti-dsDNA positive. Proximal muscle weakness was the most frequent MG-related symptom (9/16), while 11/16 patients were anti-acetylcholine receptor (anti-AChR) antibody positive and 9/16 had diagnostic electromyography (EMG). These data suggest that MG should to be included in the differential diagnosis of lupus patients with fatigue and muscular weakness together with inflammatory and drug-induced myopathy.
I Castrejón; K Shum; C-E Tseng; A Askanase
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2011-07-04
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  40     ISSN:  1502-7732     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-02-16     Revised Date:  2012-12-05    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Department of Rheumatology, Princess University Hospital, Madrid, Spain.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Antirheumatic Agents / therapeutic use
Diagnosis, Differential
Fatigue / etiology
Glucocorticoids / therapeutic use
Lupus Erythematosus, Systemic / complications*,  drug therapy,  immunology
Middle Aged
Muscle Weakness / etiology
Myasthenia Gravis / complications*,  drug therapy,  immunology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antirheumatic Agents; 0/Glucocorticoids
Comment In:
Scand J Rheumatol. 2012 Oct;41(5):409; author reply 409-10   [PMID:  23043444 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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