Document Detail

Association between mild anemia and executive function impairment in community-dwelling older women: The Women's Health and Aging Study II.
MedLine Citation:
PMID:  16970654     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the relationship between mild anemia and executive function in community-dwelling older women.
DESIGN: Cross-sectional.
SETTING: Community-based.
PARTICIPANTS: High-functioning subjects participating in the baseline assessment of the Women's Health and Aging Study (WHAS) II, Baltimore, Maryland, 1994 to 1996. WHAS II eligibility criteria included aged 70 to 80, a Mini-Mental State Examination score of 24 or greater, and absence of advanced disability (difficulty in no more than 1 domain of physical function). Included in this study were 364 subjects with a hemoglobin concentration 10 g/dL or greater and known executive function status.
MEASUREMENTS: Trail Making Test (TMT) Parts B and A. Tertiles of time to complete each test were used to define best (bottom), intermediate, and worst (top) performance. Tertiles of the difference TMT-B minus TMT-A were calculated. Anemia defined as hemoglobin concentration less than 12 g/dL.
RESULTS: The percentage of subjects in the worst TMT-B, TMT-A, and TMT-B minus TMT-A performance tertile was highest for those with anemia. Prevalent anemia substantially increased the likelihood of performing worst (as opposed to best) on the TMT-B (odds ratio (OR) = 5.2, 95% confidence interval (CI) = 1.3-20.5), TMT-A (OR = 4.8, 95% CI = 1.5-15.6), and TMT-B minus TMT-A (OR = 4.2, 95% CI = 1.0-17.2), even after controlling for age, education, race, prevalent diseases, and relevant physiological and functional parameters.
CONCLUSION: This study provides preliminary evidence in support of the hypothesis that mild anemia might be an independent risk factor for executive function impairment in community-dwelling older adults. Whether such an association is causal or noncausal remains to be determined.
Paulo H M Chaves; Michelle C Carlson; Luigi Ferrucci; Jack M Guralnik; Richard Semba; Linda P Fried
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  54     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2006-10-20     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1429-35     Citation Subset:  IM    
Center on Aging and Health and Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
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MeSH Terms
Aged, 80 and over
Anemia / blood,  psychology*
Cognition Disorders / blood,  etiology*
Cross-Sectional Studies
Educational Status
Health Status
Hemoglobins / metabolism
Residence Characteristics
Trail Making Test
Grant Support
M01-RR000052/RR/NCRR NIH HHS; P30 AG021334/AG/NIA NIH HHS; R01 AG11703/AG/NIA NIH HHS; Z99 AG999999/AG/NIA NIH HHS
Reg. No./Substance:

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