Document Detail


Association between migraine and a functional polymorphism at the dopamine beta-hydroxylase locus.
MedLine Citation:
PMID:  19219470     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Migraine is a common neurological disorder with a significant genetic component. Although a number of linkage and association studies have been undertaken, the number and identity of all migraine susceptibility genes has yet to be defined. The existence of dopaminergic hypersensitivity in migraine has been recognised on a pharmacological basis and some studies have reported genetic association between migraine and dopamine-related gene variants. Our laboratory has previously reported association of migraine with a promoter STR marker in the dopamine beta hydroxylase (DBH) gene. In the present study, we analysed two additional DBH markers in two independent migraine case-control cohorts. These two markers are putative functional SNPs, one within the promoter (-1021C-->T) and another SNP (+1603C-->T) in exon 11 of the DBH gene. The results showed a significant association for allelic and genotypic frequency distribution between the DBH marker in the promoter and migraine in the first (P = 0.004 and P = 0.012, respectively) and the second (P = 0.013 and P = 0.031, respectively) tested cohorts. There was no association observed between either genotype and/or allelic frequencies for the DBH marker located in exon 11 and migraine (P > or = 0.05). The promoter DBH marker, reported associated with migraine in this study, has been shown to affect up to 52% of plasma DBH activity. Varying DBH activity levels have been postulated to be involved in migraine process with an increase of dopamine, resulting from a lower DBH activity shown positively correlated with migraine severity. It is plausible that the functional promoter variant of DBH may play a role in the migraine disorder.
Authors:
F Fernandez; N Colson; S Quinlan; J MacMillan; R A Lea; L R Griffiths
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-14
Journal Detail:
Title:  Neurogenetics     Volume:  10     ISSN:  1364-6753     ISO Abbreviation:  Neurogenetics     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709714     Medline TA:  Neurogenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-208     Citation Subset:  IM    
Affiliation:
Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Gold Coast, 9726 Queensland, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Dopamine beta-Hydroxylase / genetics*
Female
Genetic Markers
Genetic Predisposition to Disease*
Genetics, Population
Genotype
Humans
Male
Migraine Disorders / genetics*,  physiopathology
Phenotype
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/Genetic Markers; EC 1.14.17.1/Dopamine beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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