Document Detail


Association between microchimerism and multiple sclerosis in Canadian twins.
MedLine Citation:
PMID:  16843535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microchimerism, the persistence of foreign cells thought to derive from previous pregnancies, has been associated with autoimmune diseases. A maternal parent-of-origin effect in MS remains unexplained. We tested for microchimerism in monozygotic and dizygotic twin-pairs with MS. Microchimerism was associated with MS in affected females from monozygotic concordant pairs when compared to both affected (p=0.020) and unaffected (p=0.025) females in monozygotic discordant pairs. Microchimerism was increased in affected females of dizygotic discordant pairs (p=0.059). The rate of microchimerism was significantly higher in affected twins than in unaffected co-twins (p=0.0059). These observations show an association in twins between the presence of microchimerism and having MS.
Authors:
Cristen J Willer; Blanca M Herrera; Katie M E Morrison; A D Sadovnick; George C Ebers;
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Publication Detail:
Type:  Journal Article; Twin Study     Date:  2006-07-14
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  179     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-51     Citation Subset:  IM    
Affiliation:
Department of Clinical Neurology, University of Oxford, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Canada
Chimerism*
Diseases in Twins*
Female
Humans
Male
Multiple Sclerosis / genetics*
Pedigree
Polymerase Chain Reaction
Twins, Dizygotic / genetics*
Twins, Monozygotic / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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