| Association between microchimerism and multiple sclerosis in Canadian twins. | |
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MedLine Citation:
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PMID: 16843535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microchimerism, the persistence of foreign cells thought to derive from previous pregnancies, has been associated with autoimmune diseases. A maternal parent-of-origin effect in MS remains unexplained. We tested for microchimerism in monozygotic and dizygotic twin-pairs with MS. Microchimerism was associated with MS in affected females from monozygotic concordant pairs when compared to both affected (p=0.020) and unaffected (p=0.025) females in monozygotic discordant pairs. Microchimerism was increased in affected females of dizygotic discordant pairs (p=0.059). The rate of microchimerism was significantly higher in affected twins than in unaffected co-twins (p=0.0059). These observations show an association in twins between the presence of microchimerism and having MS. |
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Authors:
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Cristen J Willer; Blanca M Herrera; Katie M E Morrison; A D Sadovnick; George C Ebers; |
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Publication Detail:
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Type: Journal Article; Twin Study Date: 2006-07-14 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 179 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-02 Completed Date: 2006-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-51 Citation Subset: IM |
Affiliation:
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Department of Clinical Neurology, University of Oxford, Oxford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Canada Chimerism* Diseases in Twins* Female Humans Male Multiple Sclerosis / genetics* Pedigree Polymerase Chain Reaction Twins, Dizygotic / genetics* Twins, Monozygotic / genetics* |
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