| Association between maternal-fetal genetic histocompatibility and maternal undernutrition in mice: influence on intrauterine growth. | |
| | |
MedLine Citation:
|
PMID: 16680329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of this study was to evaluate the effects of maternal-fetal genetic histocompatibility and the association of that condition with maternal undernutrition regarding fetal growth and litter size. STUDY DESIGN: Fetuses that were either syngeneic or allogeneic with the mothers were bred, using mice of well-defined syngeneic strains (A/J and Balb/c). Pregnant mice were fed using either unrestricted normal diet with 22% protein, consumed ad libitum, or a diet containing 14% protein, with intake restricted to 70% of that consumed by the unrestricted group. At the end of gestation, the number of fetoplacental units and fetal losses, the fetal and placental weight, and the weights of fetal brain and liver were recorded. RESULTS: Fetuses from undernourished mothers showed a reduction in body, placental, and brain weight (P < 0.01); the association of undernourishment with maternal-fetal genetic compatibility resulted in a greater impairment of fetal growth (P < 0.01). A reduction in the number of viable fetuses per female in the dietary-restricted groups was observed. (P < 0.01). Although the concurrence of maternal-fetal genetic compatibility resulted in a trend towards a greater reduction in the number of viable fetuses as well as in a higher rate of fetal loss, these differences did not reach statistical significance. CONCLUSIONS: In mice, the occurrence of maternal-fetal genetic histocompatibility alone did not change fetal growth; maternal undernutrition during pregnancy resulted in growth stunting of progenies with reduction of litter size; and the association of these 2 factors produced greater reduction of fetal weight. |
| | |
Authors:
|
Celso M Rebello; José Lauro A Ramos |
Related Documents
:
|
535549 - Deciduous teeth contain histories of developmental disturbances. 12854369 - Factors influencing fetal growth. 12953179 - Timing is everything: a reconsideration of fetal growth velocity patterns identifies th... 12704709 - Human physiological adaptation to pregnancy: inter- and intraspecific perspectives. 12124909 - Size and shape changes during late fetal growth (137-157 gestational days) in the pigta... 19820049 - Effects of maternal nutrition on conceptus growth and offspring performance: implicatio... 9438949 - Fetal heart rate (fhr) pathology in labor related to preceeding doppler sonographic res... 9348249 - Concentration of anti-d antibodies in rh(d) alloimmunized pregnant women, as a predicto... 12614949 - Risk factors for unexplained antepartum fetal death in norway 1967-1998. |
Publication Detail:
|
Type: Journal Article Date: 2006-04-25 |
Journal Detail:
|
Title: Clinics (São Paulo, Brazil) Volume: 61 ISSN: 1807-5932 ISO Abbreviation: Clinics (Sao Paulo) Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-05-08 Completed Date: 2006-08-18 Revised Date: 2009-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 101244734 Medline TA: Clinics (Sao Paulo) Country: Brazil |
Other Details:
|
Languages: eng Pagination: 127-32 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, São Paulo University Medical School, São Paulo, SP, Brazil. celso.rebello@uol.com.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diet Female Fetal Development* / genetics Fetal Growth Retardation / etiology*, genetics Fetus / immunology Histocompatibility Antigens / genetics* Malnutrition / complications* Mice Mice, Inbred BALB C Pregnancy / immunology Pregnancy Complications* Weight Gain |
| Chemical | |
Reg. No./Substance:
|
0/Histocompatibility Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multilocus genotyping of Cryptosporidium hominis associated with diarrhea outbreak in a day care uni...
Next Document: Results of meniscectomy for treatment of isolated meniscal injuries: correlation between results and...