Document Detail

Association between maternal-fetal genetic histocompatibility and maternal undernutrition in mice: influence on intrauterine growth.
MedLine Citation:
PMID:  16680329     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the effects of maternal-fetal genetic histocompatibility and the association of that condition with maternal undernutrition regarding fetal growth and litter size. STUDY DESIGN: Fetuses that were either syngeneic or allogeneic with the mothers were bred, using mice of well-defined syngeneic strains (A/J and Balb/c). Pregnant mice were fed using either unrestricted normal diet with 22% protein, consumed ad libitum, or a diet containing 14% protein, with intake restricted to 70% of that consumed by the unrestricted group. At the end of gestation, the number of fetoplacental units and fetal losses, the fetal and placental weight, and the weights of fetal brain and liver were recorded. RESULTS: Fetuses from undernourished mothers showed a reduction in body, placental, and brain weight (P < 0.01); the association of undernourishment with maternal-fetal genetic compatibility resulted in a greater impairment of fetal growth (P < 0.01). A reduction in the number of viable fetuses per female in the dietary-restricted groups was observed. (P < 0.01). Although the concurrence of maternal-fetal genetic compatibility resulted in a trend towards a greater reduction in the number of viable fetuses as well as in a higher rate of fetal loss, these differences did not reach statistical significance. CONCLUSIONS: In mice, the occurrence of maternal-fetal genetic histocompatibility alone did not change fetal growth; maternal undernutrition during pregnancy resulted in growth stunting of progenies with reduction of litter size; and the association of these 2 factors produced greater reduction of fetal weight.
Celso M Rebello; José Lauro A Ramos
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Publication Detail:
Type:  Journal Article     Date:  2006-04-25
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  61     ISSN:  1807-5932     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-08-18     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Department of Pediatrics, São Paulo University Medical School, São Paulo, SP, Brazil.
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MeSH Terms
Fetal Development* / genetics
Fetal Growth Retardation / etiology*,  genetics
Fetus / immunology
Histocompatibility Antigens / genetics*
Malnutrition / complications*
Mice, Inbred BALB C
Pregnancy / immunology
Pregnancy Complications*
Weight Gain
Reg. No./Substance:
0/Histocompatibility Antigens

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