| Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease. | |
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MedLine Citation:
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PMID: 10336597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has remained unclear whether genetic background of patients with atopic eczema (AE) alone is identical to that of patients with both AE and atopic respiratory disease. OBJECTIVE: We aimed to assess whether there is a genetic difference between these two groups of AE patients. METHOD: We determined the genotype with regard to an allelic polymorphism in the gene for mast cell chymase (MCC; a serine protease secreted from mast cells) in 169 AE patients. RESULTS: MCC genotype was significantly associated with pure AE patients who did not have a predisposition to atopic respiratory disease and whose serum IgE concentration was < 500 IU/mL. The distribution of MCC genotypes also differed significantly between the latter patients and those AE patients with bronchial asthma and a serum IgE concentration of > 2000 IU/mL. CONCLUSION: These results suggest that pure AE is associated with genetic variants of MCC, and that the genetic basis of pure AE differs from that of AE associated with atopic asthma. |
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Authors:
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K Tanaka; H Sugiura; M Uehara; H Sato; T Hashimoto-Tamaoki; J Furuyama |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 29 ISSN: 0954-7894 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-07-14 Completed Date: 1999-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 800-3 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Shiga University of Medical Science, Seta, Otsu, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asthma / complications, genetics* Child Chymases Eczema / complications, genetics* Female Genotype Humans Hypersensitivity / blood, complications, genetics* Immunoglobulin E / blood Male Mast Cells / enzymology* Rhinitis, Allergic, Seasonal / complications, genetics* Serine Endopeptidases / genetics* |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.39/Chymases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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