Document Detail

Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease.
MedLine Citation:
PMID:  10336597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has remained unclear whether genetic background of patients with atopic eczema (AE) alone is identical to that of patients with both AE and atopic respiratory disease. OBJECTIVE: We aimed to assess whether there is a genetic difference between these two groups of AE patients. METHOD: We determined the genotype with regard to an allelic polymorphism in the gene for mast cell chymase (MCC; a serine protease secreted from mast cells) in 169 AE patients. RESULTS: MCC genotype was significantly associated with pure AE patients who did not have a predisposition to atopic respiratory disease and whose serum IgE concentration was < 500 IU/mL. The distribution of MCC genotypes also differed significantly between the latter patients and those AE patients with bronchial asthma and a serum IgE concentration of > 2000 IU/mL. CONCLUSION: These results suggest that pure AE is associated with genetic variants of MCC, and that the genetic basis of pure AE differs from that of AE associated with atopic asthma.
K Tanaka; H Sugiura; M Uehara; H Sato; T Hashimoto-Tamaoki; J Furuyama
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  29     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-14     Completed Date:  1999-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  800-3     Citation Subset:  IM    
Department of Dermatology, Shiga University of Medical Science, Seta, Otsu, Japan.
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MeSH Terms
Asthma / complications,  genetics*
Eczema / complications,  genetics*
Hypersensitivity / blood,  complications,  genetics*
Immunoglobulin E / blood
Mast Cells / enzymology*
Rhinitis, Allergic, Seasonal / complications,  genetics*
Serine Endopeptidases / genetics*
Reg. No./Substance:
37341-29-0/Immunoglobulin E; EC 3.4.21.-/Serine Endopeptidases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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