Document Detail


Association between mast cell chymase genotype and atopic eczema: comparison between patients with atopic eczema alone and those with atopic eczema and atopic respiratory disease.
MedLine Citation:
PMID:  10336597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It has remained unclear whether genetic background of patients with atopic eczema (AE) alone is identical to that of patients with both AE and atopic respiratory disease. OBJECTIVE: We aimed to assess whether there is a genetic difference between these two groups of AE patients. METHOD: We determined the genotype with regard to an allelic polymorphism in the gene for mast cell chymase (MCC; a serine protease secreted from mast cells) in 169 AE patients. RESULTS: MCC genotype was significantly associated with pure AE patients who did not have a predisposition to atopic respiratory disease and whose serum IgE concentration was < 500 IU/mL. The distribution of MCC genotypes also differed significantly between the latter patients and those AE patients with bronchial asthma and a serum IgE concentration of > 2000 IU/mL. CONCLUSION: These results suggest that pure AE is associated with genetic variants of MCC, and that the genetic basis of pure AE differs from that of AE associated with atopic asthma.
Authors:
K Tanaka; H Sugiura; M Uehara; H Sato; T Hashimoto-Tamaoki; J Furuyama
Related Documents :
8771867 - Scleredema of buschke: a report of seven cases.
12399757 - Treatment of dyshidrotic hand dermatitis with intradermal botulinum toxin.
17335547 - Elevated levels of plasma matrix metalloproteinase-9 in patients with atopic dermatitis...
7962747 - Congenital "self-healing" langerhans cell histiocytosis: the need for long-term follow-up.
22156587 - Association of hypo- and hyperkalemia with disease progression and mortality in males w...
14650457 - Patient-specific factors affecting patient-controlled analgesia dosing.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  29     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-14     Completed Date:  1999-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  800-3     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Shiga University of Medical Science, Seta, Otsu, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asthma / complications,  genetics*
Child
Chymases
Eczema / complications,  genetics*
Female
Genotype
Humans
Hypersensitivity / blood,  complications,  genetics*
Immunoglobulin E / blood
Male
Mast Cells / enzymology*
Rhinitis, Allergic, Seasonal / complications,  genetics*
Serine Endopeptidases / genetics*
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.39/Chymases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association studies on beta2-adrenoceptor polymorphisms and enhanced IgE responsiveness in an atopic...
Next Document:  Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi.