| Association between manganese superoxide dismutase polymorphism and risk of lung cancer. | |
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MedLine Citation:
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PMID: 19167605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Manganese superoxide dismutase (MnSOD) is one of the major enzymes responsible for the defense against oxidative damage due to reactive oxygen species (ROS) in the mitochondria. C-->T substitution in the MnSOD gene (SOD2) produces an Ala-->Val change at amino acid 16, in the mitochondrial targeting sequence of the MnSOD precursor. This seems to reduce transport of the enzyme into mitochondria, decreasing its defense capacity against oxidative stress. The present case-control study was conducted to investigate the association of SOD2 genetic polymorphism with individual susceptibility to lung cancer. Ala16Val polymorphisms were determined using polymerase chain reaction, restriction fragment length polymorphism mapping, and agarose gel electrophoresis techniques in 100 lung cancer patients and 50 healthy control subjects. The frequency of the Val allele (OR=1.297, 95% CI=1.095-1.536) and the Val/Val genotype (OR=7.00, 95% CI=2.282-21.476) was significantly higher in lung cancer patients than in control subjects. There was a combined effect of Val/Val genotype as a genetic factor with smoking as an environment factor (OR=2.24). The increase in risk of lung cancer was lesser with this combined effect than with the Val/Val genotype alone. Thus, the Val/Val genotype of SOD2 may be associated with lung cancer in a Turkish population. |
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Authors:
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Jasmina Zejnilovic; Nuriye Akev; Hulya Yilmaz; Turgay Isbir |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 189 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 1-4 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Genetic Predisposition to Disease Genotype Humans Lung Neoplasms / genetics* Oxidative Stress / genetics Polymorphism, Genetic* Risk Factors Superoxide Dismutase / genetics* Turkey Valine / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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7004-03-7/Valine; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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