Document Detail


Association between manganese exposure through drinking water and infant mortality in Bangladesh.
MedLine Citation:
PMID:  17637930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. METHODS: In 2001, drinking water samples were collected, a history of well use was obtained, and a history of birth outcomes was ascertained. To avoid misclassification of exposure, women were included only if they had been drinking from the same well for most of their childbearing years (marriage years - well years </= 2). Of a total of 26,002 births (among 6,537 mothers), 3,837 children were born to women with this profile. The current analysis was based on the portion of these infants (n = 3,824) with recorded exposure and outcome status, 335 of whom died before reaching 1 year of age. RESULTS: Infants exposed to water manganese greater than or equal to the 2003 World Health Organization standard of 0.4 mg/L had an elevated mortality risk during the first year of life compared with unexposed infants [odds ratio (OR) = 1.8; 95% confidence interval (CI), 1.2-2.6]. Adjustment for water arsenic, indicators of social class, and other variables did not appreciably alter these results. When the population was restricted to infants born to recently married parents (marriage year 1991 or after), this elevation was more pronounced (OR = 3.4; 95% CI, 1.5-7.9). CONCLUSIONS: These preliminary findings indicate a possible association between manganese exposure and infant mortality. However, given the methodologic limitations of this study, the association needs to be confirmed through future work.
Authors:
Danella Hafeman; Pam Factor-Litvak; Zhongqi Cheng; Alexander van Geen; Habibul Ahsan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Environmental health perspectives     Volume:  115     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1107-12     Citation Subset:  IM    
Affiliation:
Mailman School of Public Health, Columbia University, New York, New York 10032, USA. dmh2002@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Bangladesh / epidemiology
Cohort Studies
Female
Humans
Infant
Infant Mortality*
Longitudinal Studies
Male
Manganese / toxicity*
Middle Aged
Water Supply*
Grant Support
ID/Acronym/Agency:
P30ES09089/ES/NIEHS NIH HHS; P42ES10349/ES/NIEHS NIH HHS; R01CA102484/CA/NCI NIH HHS; R01CA107431/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
7439-96-5/Manganese
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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