| Association between macular microcirculation and soluble intercellular adhesion molecule-1 in patients with macular edema and retinal vein occlusion. | |
| | |
MedLine Citation:
|
PMID: 20309574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: In patients who have macular edema secondary to retinal vein occlusion, the role of vasoactive molecules such as growth factors and the influence of molecules related to leukocyte adhesion need to be investigated further. METHODS: A prospective study was performed to investigate the relations between perifoveal capillary blood flow velocity and the vitreous levels of vascular endothelial growth factor (VEGF) and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with macular edema and retinal vein occlusion. Undiluted vitreous specimens were obtained from 11 eyes of 11 patients with macular edema (nine had branch retinal vein occlusion and two had central retinal vein occlusion). VEGF and sICAM-1 levels were measured by enzyme-linked immunoabsorbent assay. Before vitreous sampling, perifoveal capillary blood flow velocity was measured by fluorescein angiography with a scanning laser ophthalmoscope and the tracing method. The relations between perifoveal capillary blood flow velocity and the vitreous levels of VEGF and sICAM-1 were investigated. RESULTS: There was a significant correlation between perifoveal capillary blood flow velocity and the vitreous level of sICAM-1 (rho = -0.7303, p = 0.03). In contrast, there was no significant association between blood flow velocity and the vitreous level of VEGF (rho = -0.1458, p = 0.67). CONCLUSIONS: The vitreous level of sICAM-1 is associated with perifoveal capillary blood flow velocity in patients who have retinal vein occlusion and macular edema. |
| | |
Authors:
|
Hidetaka Noma; Hideharu Funatsu; Kumi Sakata; Tatsuya Mimura; Sadao Hori |
Related Documents
:
|
1553214 - Gaze-induced amaurosis from central retinal artery compression. 1357064 - Effects of lofexidine, an alpha 2-adrenoreceptor agonist, on ocular blood flow and ion ... 7197634 - Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier perm... 12752054 - The effects of latanoprost and brimonidine on blood flow velocity of the retrobulbar ve... 6657864 - Epinephrine and norepinephrine responses in continuously collected human plasma to a se... 2719994 - Free tryptophan decrease in jaundiced newborn infants during phototherapy. |
Publication Detail:
|
Type: Journal Article Date: 2010-03-23 |
Journal Detail:
|
Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 248 ISSN: 1435-702X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-08-23 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1515-8 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96, Owada-shinden, Yachiyo, Chiba, 276-8524, Japan. nomahide@tymc.twmu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Flow Velocity Capillaries Enzyme-Linked Immunosorbent Assay Female Fluorescein Angiography Humans Intercellular Adhesion Molecule-1 / metabolism* Macular Edema / metabolism, physiopathology*, surgery Male Microcirculation Middle Aged Ophthalmoscopy Prospective Studies Retinal Vein Occlusion / metabolism, physiopathology* Retinal Vessels / physiology* Vascular Endothelial Growth Factor A Vitrectomy Vitreous Body / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 126547-89-5/Intercellular Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Idiopathic maculopathy in eyes with regressed retinopathy of prematurity.
Next Document: The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the muci...