Document Detail

Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study.
MedLine Citation:
PMID:  22383587     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Particulate air pollution is associated with cardiovascular events, but the mechanisms are not fully understood. The main objective was to assess the relationship between long-term exposure to traffic-related air pollution and blood pressure (BP).
METHODS: The authors used longitudinal data from 853 elderly men participating in the Veterans Administration Normative Aging Study, followed during 1996-2008. Long-term average exposures to traffic particles were created from daily predictions of black carbon (BC) exposure at the geocoded address of each subject, using a validated spatiotemporal model based on ambient monitoring at 82 Boston-area locations. The authors examined the association of these exposures with BP using a mixed model. The authors included the following covariates: age, body mass index, smoking, alcohol, fasting glucose, creatinine clearance, use of cardiovascular medication, education, census-level poverty, day of week and season of clinical visit.
RESULTS: The authors found significant positive associations between 1-year average BC exposure and both systolic and diastolic blood pressure. An IQR increase in 1-year average BC exposure (0.32 μg/m(3)) was associated with a 2.64 mm Hg increase in systolic blood pressure (95% CI 1.47 to 3.80) and a 2.41 mm Hg increase in diastolic blood pressure (95% CI 1.77 to 3.05).
CONCLUSIONS: Long-term exposure to traffic particles is associated with increased BP, which may explain part of the association with myocardial infarctions and cardiovascular deaths reported in cohort studies.
Joel Schwartz; Stacey E Alexeeff; Irina Mordukhovich; Alexandros Gryparis; Pantel Vokonas; Helen Suh; Brent A Coull
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-03-01
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  69     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-07-27     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
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MeSH Terms
Air Pollutants / analysis,  toxicity*
Air Pollution / adverse effects*,  analysis,  statistics & numerical data
Blood Pressure / drug effects*
Follow-Up Studies
Health Surveys
Hypertension / chemically induced*
Inhalation Exposure / adverse effects*,  analysis,  statistics & numerical data
Linear Models
Longitudinal Studies
Soot / analysis,  toxicity*
United States
United States Department of Veterans Affairs
Vehicle Emissions / analysis,  toxicity*
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Soot; 0/Vehicle Emissions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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