| Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study. | |
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MedLine Citation:
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PMID: 22383587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Particulate air pollution is associated with cardiovascular events, but the mechanisms are not fully understood. The main objective was to assess the relationship between long-term exposure to traffic-related air pollution and blood pressure (BP). METHODS: The authors used longitudinal data from 853 elderly men participating in the Veterans Administration Normative Aging Study, followed during 1996-2008. Long-term average exposures to traffic particles were created from daily predictions of black carbon (BC) exposure at the geocoded address of each subject, using a validated spatiotemporal model based on ambient monitoring at 82 Boston-area locations. The authors examined the association of these exposures with BP using a mixed model. The authors included the following covariates: age, body mass index, smoking, alcohol, fasting glucose, creatinine clearance, use of cardiovascular medication, education, census-level poverty, day of week and season of clinical visit. RESULTS: The authors found significant positive associations between 1-year average BC exposure and both systolic and diastolic blood pressure. An IQR increase in 1-year average BC exposure (0.32 μg/m(3)) was associated with a 2.64 mm Hg increase in systolic blood pressure (95% CI 1.47 to 3.80) and a 2.41 mm Hg increase in diastolic blood pressure (95% CI 1.77 to 3.05). CONCLUSIONS: Long-term exposure to traffic particles is associated with increased BP, which may explain part of the association with myocardial infarctions and cardiovascular deaths reported in cohort studies. |
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Authors:
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Joel Schwartz; Stacey E Alexeeff; Irina Mordukhovich; Alexandros Gryparis; Pantel Vokonas; Helen Suh; Brent A Coull |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-03-01 |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 69 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-07 Completed Date: 2012-07-27 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 422-7 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Air Pollutants / analysis, toxicity* Air Pollution / adverse effects*, analysis, statistics & numerical data Blood Pressure / drug effects* Boston Follow-Up Studies Health Surveys Humans Hypertension / chemically induced* Inhalation Exposure / adverse effects*, analysis, statistics & numerical data Linear Models Longitudinal Studies Male Soot / analysis, toxicity* United States United States Department of Veterans Affairs Vehicle Emissions / analysis, toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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ES00002/ES/NIEHS NIH HHS; ES015172-01/ES/NIEHS NIH HHS; R01 ES015172/ES/NIEHS NIH HHS; T32 ES007018/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Soot; 0/Vehicle Emissions |
| Comments/Corrections | |
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