| Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. | |
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MedLine Citation:
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PMID: 15838535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with schizophrenia, bipolar disorder and recurrent major depression. We now report evidence for association between bipolar disorder and schizophrenia and this locus in the general Scottish population. A systematic study of linkage disequilibrium in a representative sample of the Scottish population was undertaken across the 510 kb of TRAX and DISC1. SNPs representing each haplotype block were selected for case-control association studies of both schizophrenia and bipolar disorder. Significant association with bipolar disorder in women P=0.00026 (P=0.0016 in men and women combined) was detected in a region of DISC1. This same region also showed nominally significant association with schizophrenia in both men and women combined, P=0.0056. Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P<0.01. Only the association between bipolar women and DISC1 remained significant after correction for multiple testing. This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family. |
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Authors:
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P A Thomson; N R Wray; J K Millar; K L Evans; S Le Hellard; A Condie; W J Muir; D H R Blackwood; D J Porteous |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular psychiatry Volume: 10 ISSN: 1359-4184 ISO Abbreviation: Mol. Psychiatry Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-24 Completed Date: 2005-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9607835 Medline TA: Mol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 657-68, 616 Citation Subset: IM |
Affiliation:
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Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK. Pippa.Thomson@ed.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bipolar Disorder
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epidemiology,
genetics* Case-Control Studies DNA-Binding Proteins / genetics* Female Genetic Predisposition to Disease / genetics* Haplotypes Humans Linkage Disequilibrium Male Nerve Tissue Proteins / genetics* Pedigree Polymorphism, Single Nucleotide / genetics Schizophrenia / epidemiology, genetics* Scotland / epidemiology Sex Factors Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/DISC1 protein, human; 0/DNA-Binding Proteins; 0/Nerve Tissue Proteins; 0/TSNAX protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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