Document Detail


Association between lithium use and thyrotoxicosis caused by silent thyroiditis.
MedLine Citation:
PMID:  11678833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the incidence of silent thyroiditis in lithium users and characterize lithium-associated thyrotoxicosis. DESIGN: Retrospective record review. PATIENTS: 400 consecutive patients (300 with Graves' disease and 100 with silent thyroiditis) who underwent radioiodine scanning of the thyroid. MEASUREMENTS: Odds of lithium exposure. RESULTS: The odds of lithium exposure were increased 4.7-fold in patients with silent thyroiditis compared with those with Graves' disease (95% CI: 1.3, 17). Lithium-associated silent thyroiditis occurred with an incidence rate of approximately 1.3 cases per 1000 person-years, and lithium-associated thyrotoxicosis occurred with an incidence rate of approximately 2.7 cases per 1000 person-years, higher than the reported incidence rates of silent thyroiditis (< 0.03-0.28 cases per 1000 person-years) and of thyrotoxicosis (0.8-1.2 cases per 1000 person-years) in the general population. CONCLUSION: Thyrotoxicosis caused by silent thyroiditis might be associated with lithium use.
Authors:
K K Miller; G H Daniels
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  55     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-26     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  501-8     Citation Subset:  IM    
Affiliation:
Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimanic Agents / adverse effects*,  therapeutic use
Female
Graves Disease / drug therapy,  metabolism
Humans
Iodine Radioisotopes / diagnostic use
Lithium Carbonate / adverse effects*,  therapeutic use
Male
Middle Aged
Retrospective Studies
Thyroid Gland / metabolism
Thyroiditis / chemically induced*,  drug therapy,  metabolism
Thyrotoxicosis / chemically induced*,  metabolism
Thyroxine / blood
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Antimanic Agents; 0/Iodine Radioisotopes; 554-13-2/Lithium Carbonate; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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