| Association between lipid profile and circulating concentrations of estrogens in young men. | |
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MedLine Citation:
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PMID: 18639879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Men show higher rates of cardiovascular morbidity and mortality than pre-menopausal women and this sexual dimorphism may be related to sex-specific effects of sex steroids on cardiovascular risk factors. Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men. METHODS: We examined associations of estradiol and estrone and their precursors (total testosterone and androstenedione) with traditional cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age: 19 years), apparently healthy Polish men. RESULTS: Total estradiol was associated with total cholesterol (p=0.006) and high-density lipoprotein cholesterol (HDL-C) (p<0.001) and estrone showed the strongest associations with both total cholesterol (p<0.001) and low-density lipoprotein cholesterol (LDL-C) (p<0.001) in the unadjusted ANOVA analysis. In the multivariable adjusted models in which other independent variables were held as constant one standard deviation increase in estradiol level was associated with 6%-standard deviation increase in total cholesterol (standardized beta=0.06, p=0.038) and 6%-standard deviation decrease in HDL-cholesterol (standardized beta=-0.06, p=0.036). An increase in estrone levels by one standard deviation was associated with respective 12%- and 13%-standard deviation increases in total cholesterol (standardized beta=0.12, p<0.001) and LDL-cholesterol levels (standardized beta=0.12, p<0.001) after controlling for other predictors of lipids. Estrone correlated linearly with androstenedione (r=0.28, p<0.001) but there was no correlation between estradiol and testosterone. Estrogens retained their independent associations with lipids after adjustment for their biochemical precursors in the multivariable analysis. CONCLUSIONS: Increased levels of estrogens are associated with unfavourable lipid profile in men and this association is present early in life, before apparent manifestations of cardiovascular disease. |
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Authors:
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Maciej Tomaszewski; Fadi J Charchar; Christine Maric; Roman Kuzniewicz; Mateusz Gola; Wladyslaw Grzeszczak; Nilesh J Samani; Ewa Zukowska-Szczechowska |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-06-17 |
Journal Detail:
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Title: Atherosclerosis Volume: 203 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-02 Completed Date: 2009-09-09 Revised Date: 2011-05-30 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. mt142@le.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Pressure Body Mass Index Cardiovascular Diseases / diagnosis Cardiovascular System Estradiol / blood* Estrogens / blood* Estrone / blood* Humans Lipids / chemistry* Male Phenotype Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R03 TW007165/TW/FIC NIH HHS; R03 TW007165-03/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Lipids; 50-28-2/Estradiol; 53-16-7/Estrone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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