Document Detail


Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population.
MedLine Citation:
PMID:  15019285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine in a broad spectrum of physiological processes. Previous investigations have observed that levels of the IL-1beta were higher in essential hypertensive patients and the IL-1beta gene polymorphism has been shown to be related to IL-1 production. We hypothesized that genetically determined differences in activity or responsiveness of cytokine(s) might contribute to hypertension. In this report, we utilized a family-based design to test the association between the IL-1beta C(-511)T polymorphism and blood pressure levels in hypertensive patients chosen from rural communities in Anhui, China. In men, carriers of the IL-1beta (-511)*C allele were found to have lower systolic (P = 0.049) blood pressure levels compared with T homozygotes, which conforms to an additive effect model. By contrast, no significant association between the IL-1beta gene and blood pressure levels was revealed in women. Our results suggested a significant role of the IL-1beta C(-511)T polymorphism in the control of blood pressure in Chinese hypertensives.
Authors:
Guo Huang; Tianhua Niu; Shaojie Peng; Daijun Ling; Jing Liu; Xuejun Zhang; Xiping Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunology letters     Volume:  91     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-15     Completed Date:  2004-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Affiliation:
School of Life Sciences, University of Science and Technology of China, Hefei.
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MeSH Terms
Descriptor/Qualifier:
Asian Continental Ancestry Group / genetics*
Blood Pressure / genetics*
Cytosine / metabolism
Female
Genetic Predisposition to Disease / genetics
Humans
Hypertension / genetics*
Interleukin-1 / blood,  genetics*
Male
Middle Aged
Mutation / genetics
Polymorphism, Genetic / genetics*
Sex Characteristics
Thymine / metabolism
Grant Support
ID/Acronym/Agency:
ES00002/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-1; 65-71-4/Thymine; 71-30-7/Cytosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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