Document Detail


Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway.
MedLine Citation:
PMID:  21576080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Folic acid intake during pregnancy can reduce the risk of neural tube defects (NTDs) and perhaps also oral facial clefts. Maternal autoantibodies to folate receptors can impair folic acid binding. We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor α (FRα), as well as possible effects of parental demographics or prenatal exposures.
METHODS: We conducted a nested case-control study within the Norwegian Mother and Child Cohort Study. The study included mothers of children with an NTD (n = 11), cleft lip with or without cleft palate (CL/P, n= 72), or cleft palate only (CPO, n= 27), and randomly selected mothers of controls (n = 221). The inhibition of folic acid binding to FRα was measured in maternal plasma collected around 17 weeks of gestation. On the basis of prior literature, the maternal age, gravidity, education, smoking, periconception folic acid supplement use and milk consumption were considered as potential confounding factors.
RESULTS: There was an increased risk of NTDs with increased binding inhibition [adjusted odds ratio (aOR) = 1.4, 95% confidence interval (CI) 1.0-1.8]. There was no increased risk of oral facial clefts from inhibited folic acid binding to FRα (CL/P aOR = 0.7, 95% CI 0.6-1.0; CPO aOR = 1.1, 95% CI 0.8-1.4). No association was seen between smoking, folate supplementation or other cofactors and inhibition of folic acid binding to FRα.
CONCLUSIONS: Inhibition of folic acid binding to FRα in maternal plasma collected during pregnancy was associated with increased risk of NTDs but not oral facial clefts.
Authors:
A L Boyles; J L Ballard; E B Gorman; D R McConnaughey; R M Cabrera; A J Wilcox; R T Lie; R H Finnell
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-15
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  26     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-12-07     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2232-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoantibodies / analysis
Case-Control Studies
Cleft Lip / etiology
Cleft Palate / etiology
Female
Folate Receptor 1 / blood*,  immunology
Folic Acid / metabolism*
Folic Acid Deficiency / complications
Humans
Neural Tube Defects / etiology*
Norway
Pregnancy
Grant Support
ID/Acronym/Agency:
DE016315/DE/NIDCR NIH HHS; NS050249/NS/NINDS NIH HHS; R01 DE016315/DE/NIDCR NIH HHS; R01 DE016315-05/DE/NIDCR NIH HHS; R01 NS050249/NS/NINDS NIH HHS; R01 NS050249-06/NS/NINDS NIH HHS; ZIA ES049027-14/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Folate Receptor 1; 935E97BOY8/Folic Acid
Comments/Corrections

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