| Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway. | |
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MedLine Citation:
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PMID: 21576080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Folic acid intake during pregnancy can reduce the risk of neural tube defects (NTDs) and perhaps also oral facial clefts. Maternal autoantibodies to folate receptors can impair folic acid binding. We explored the relationship of these birth defects to inhibition of folic acid binding to folate receptor α (FRα), as well as possible effects of parental demographics or prenatal exposures. METHODS: We conducted a nested case-control study within the Norwegian Mother and Child Cohort Study. The study included mothers of children with an NTD (n = 11), cleft lip with or without cleft palate (CL/P, n= 72), or cleft palate only (CPO, n= 27), and randomly selected mothers of controls (n = 221). The inhibition of folic acid binding to FRα was measured in maternal plasma collected around 17 weeks of gestation. On the basis of prior literature, the maternal age, gravidity, education, smoking, periconception folic acid supplement use and milk consumption were considered as potential confounding factors. RESULTS: There was an increased risk of NTDs with increased binding inhibition [adjusted odds ratio (aOR) = 1.4, 95% confidence interval (CI) 1.0-1.8]. There was no increased risk of oral facial clefts from inhibited folic acid binding to FRα (CL/P aOR = 0.7, 95% CI 0.6-1.0; CPO aOR = 1.1, 95% CI 0.8-1.4). No association was seen between smoking, folate supplementation or other cofactors and inhibition of folic acid binding to FRα. CONCLUSIONS: Inhibition of folic acid binding to FRα in maternal plasma collected during pregnancy was associated with increased risk of NTDs but not oral facial clefts. |
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Authors:
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A L Boyles; J L Ballard; E B Gorman; D R McConnaughey; R M Cabrera; A J Wilcox; R T Lie; R H Finnell |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-15 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 26 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-18 Completed Date: 2011-12-07 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2232-8 Citation Subset: IM |
Affiliation:
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Epidemiology Branch, NIEHS/NIH, Durham, NC 27709, USA. boylesa@niehs.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / analysis Case-Control Studies Cleft Lip / etiology Cleft Palate / etiology Female Folate Receptor 1 / blood*, immunology Folic Acid / metabolism* Folic Acid Deficiency / complications Humans Neural Tube Defects / etiology* Norway Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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DE016315/DE/NIDCR NIH HHS; NS050249/NS/NINDS NIH HHS; R01 DE016315/DE/NIDCR NIH HHS; R01 DE016315-05/DE/NIDCR NIH HHS; R01 NS050249-06/NS/NINDS NIH HHS; ZIA ES049027-14/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Folate Receptor 1; 59-30-3/Folic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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