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Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension.
MedLine Citation:
PMID:  19739008     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this cross-sectional study, we examined whether hyperuricemia is associated with hypertension and the association exists in a Chinese population at a high risk of hypertension. The study population included 813 consecutively clinical patients with suspected cardiovascular disease, including the subjects with the current use of antihypertensive medications and self-reported diagnosis of hypertension. The subjects underwent three measures of blood pressure and were divided into two groups: 502 non-hypertensive subjects and 311 hypertensive subjects. Clinical and biochemical variables were measured. Results showed that uric acid level, fasting glucose, low-density lipoprotein (LDL)-cholesterol, total cholesterol and urea nitrogen were significantly higher (all p<0.05) in hypertension subjects than in non-hypertension subjects. The risk of hypertension was significantly higher in the group with higher uric acid (>400 micromol/l), compared with that with lower uric acid (<200 micromol/l) (odds ratio: 2.09, 95% CI 1.13-3.88). The odds ratio was 1.73, 95% CI 1.05-2.85 in the higher uric acid (200-400 micromol/l) group, compared with that with lower uric acid. In addition, age, gender, weight, fasting glucose, triglycerides and total cholesterol were also significantly associated with the incidence of hypertension. In age-adjusted logistic regression analysis, the effect of uric acid concentration on hypertension was attenuated. In conclusion, hyperuricemia is associated with hypertension in a Chinese population at a high risk of hypertension.
Authors:
Zhen Sui Lu; Zhen Hong Lu; Hang Lu; Shi Gui Yan; Jian An Wang; Ling Li; Wei You
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-9-08
Journal Detail:
Title:  Blood pressure     Volume:  -     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-9-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Affiliation:
Department of Orthopedic Surgery, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China.
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