| Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension. | |
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MedLine Citation:
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PMID: 19739008 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this cross-sectional study, we examined whether hyperuricemia is associated with hypertension and the association exists in a Chinese population at a high risk of hypertension. The study population included 813 consecutively clinical patients with suspected cardiovascular disease, including the subjects with the current use of antihypertensive medications and self-reported diagnosis of hypertension. The subjects underwent three measures of blood pressure and were divided into two groups: 502 non-hypertensive subjects and 311 hypertensive subjects. Clinical and biochemical variables were measured. Results showed that uric acid level, fasting glucose, low-density lipoprotein (LDL)-cholesterol, total cholesterol and urea nitrogen were significantly higher (all p<0.05) in hypertension subjects than in non-hypertension subjects. The risk of hypertension was significantly higher in the group with higher uric acid (>400 micromol/l), compared with that with lower uric acid (<200 micromol/l) (odds ratio: 2.09, 95% CI 1.13-3.88). The odds ratio was 1.73, 95% CI 1.05-2.85 in the higher uric acid (200-400 micromol/l) group, compared with that with lower uric acid. In addition, age, gender, weight, fasting glucose, triglycerides and total cholesterol were also significantly associated with the incidence of hypertension. In age-adjusted logistic regression analysis, the effect of uric acid concentration on hypertension was attenuated. In conclusion, hyperuricemia is associated with hypertension in a Chinese population at a high risk of hypertension. |
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Authors:
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Zhen Sui Lu; Zhen Hong Lu; Hang Lu; Shi Gui Yan; Jian An Wang; Ling Li; Wei You |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2009-9-08 |
Journal Detail:
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Title: Blood pressure Volume: - ISSN: 1651-1999 ISO Abbreviation: Blood Press. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-9-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: - |
Other Details:
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Languages: ENG Pagination: 1-5 Citation Subset: - |
Affiliation:
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Department of Orthopedic Surgery, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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