Document Detail


Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease.
MedLine Citation:
PMID:  18073465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Human serum paraoxonase (PON1) protects lipoproteins against oxidation by hydrolyzing lipid peroxides in oxidized low-density lipoprotein (oxLDL); therefore, it may protect against atherosclerosis. PON1 activity and polymorphisms have been inconsistently associated with carotid artery disease. The goal of this study was to clarify the role of PON1 activity and phenotype on carotid artery disease and its correlation with some inflammatory and immune markers in subjects under 55 years with early-onset carotid atherosclerosis. METHODS: Sixty patients with occlusive carotid artery disease and 30 healthy controls were enrolled. Intima-media thickness (IMT) was measured by high-resolution ultrasound of both common carotid arteries. Anti-oxLDL antibody levels were determined by ELISA. RESULTS: In the whole study population we found a negative correlation between PON1 activity and IMT (r = -0.27, p = 0.011), and between salt-stimulated PON1 activity and IMT (r = -0.24, p = 0.02). Both PON1 activity and salt-stimulated PON1 activity negatively correlated with anti-oxLDL levels (r = -0.28, p = 0.008; r = -0.26, p = 0.01). PON1 activity was lower in patients compared to controls; however, the difference was not significant.PON1 phenotype distribution of patients and controls did not differ significantly. CONCLUSION: The importance of PON1 activity as a predictive risk factor for early-onset occlusive carotid artery disease should be assessed in future studies.
Authors:
Mariann Harangi; Ildiko Seres; Maria T Magyar; Istvan Csipo; Sandor Sipka; Attila Valikovics; Laszlo Csiba; Daniel Bereczki; Gyorgy Paragh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-11
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  25     ISSN:  1421-9786     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Affiliation:
1st Department of Medicine, University of Debrecen, Debrecen, Hungary. mharangi@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aryldialkylphosphatase / blood*
Carotid Artery Diseases / blood,  enzymology*,  pathology*
Carotid Artery, Common*
Case-Control Studies
Cholesterol / blood
Female
Humans
Male
Middle Aged
Tunica Intima / pathology*
Tunica Media / pathology*
Chemical
Reg. No./Substance:
57-88-5/Cholesterol; EC 3.1.8.1/Aryldialkylphosphatase; EC 3.1.8.1/PON1 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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