| Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003. | |
| | |
MedLine Citation:
|
PMID: 15905677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE:UO1-AI-35041: To examine the impact of HIV infection and highly active antiretroviral therapy on systolic and diastolic hypertension. DESIGN: Cohort study with semi-annual assessment of the outcome. METHODS: We studied 5578 participants of the Multicenter AIDS Cohort Study with blood pressure measurements obtained between 1984 and 2003. The primary outcomes were systolic hypertension (SH; systolic blood pressure > 140 mmHg) and diastolic hypertension (DH; diastolic blood pressure > 90 mmHg). Statistical analyses were performed using multiple logistic regression with robust variance estimation. RESULTS: Of the 84 813 person-visits available for analysis, 7.3 and 8.0% showed SH and DH, respectively. Controlling for age, race, body mass index, and smoking, HIV positive men not taking antiretroviral therapy were significantly less likely than HIV negative men to have SH [odds ratio (OR), 0.79; 95% confidence interval (CI), 0.70-0.89], as were men taking mono/combination therapy (OR, 0.69; 95% CI, 0.59-0.80). The prevalence of SH among men taking highly active antiretroviral therapy (HAART) for less than 2 years was similar to that among HIV negative men (OR, 1.06; 95% CI, 0.87-1.30), but was significantly higher thereafter; for 2 to 5 years of HAART (OR, 1.51; 95% CI, 1.25-1.82) and for more than 5 years of HAART (OR, 1.70; 95% CI, 1.34-2.16). In contrast, DH was not significantly higher among men with prolonged HAART use compared to that among HIV negative controls. CONCLUSIONS: Prolonged HAART use was significantly associated with a higher prevalence of SH. This finding suggests that individuals taking HAART may be at increased risk of developing hypertension-related conditions and underscores the importance of blood pressure monitoring among these individuals. |
| | |
Authors:
|
Eric C Seaberg; Alvaro Muñoz; Ming Lu; Roger Detels; Joseph B Margolick; Sharon A Riddler; Carolyn M Williams; John P Phair; |
Related Documents
:
|
16753767 - Effect of l-arginine on blood pressure in pregnancy-induced hypertension: a randomized ... 9553447 - Blood pressure among immigrants to israel from areas affected by the chernobyl disaster. 22302247 - Long-term blood pressure control: is there a set-point in the brain? 1791607 - The association between blood pressure, calcium and other divalent cations: a populatio... 6994787 - Effect of guanfacine on blood pressure and renin activity in hypertensive patients. 2379947 - Physiological, psychological, and behavioral factors and white coat hypertension. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: AIDS (London, England) Volume: 19 ISSN: 0269-9370 ISO Abbreviation: AIDS Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-05-20 Completed Date: 2005-11-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
|
Languages: eng Pagination: 953-60 Citation Subset: IM; X |
Affiliation:
|
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA. eseaberg@jhsph.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antiretroviral Therapy, Highly Active / adverse effects* Body Mass Index Epidemiologic Methods HIV Infections / drug therapy*, epidemiology Humans Hypertension / chemically induced*, epidemiology Male Middle Aged Smoking / adverse effects United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
|
5-M01-RR-00052/RR/NCRR NIH HHS; UO1-AI-35039/AI/NIAID NIH HHS; UO1-AI-35040/AI/NIAID NIH HHS; UO1-AI-35041/AI/NIAID NIH HHS; UO1-AI-35042/AI/NIAID NIH HHS; UO1-AI-35043/AI/NIAID NIH HHS; UO1-AI-37613/AI/NIAID NIH HHS; UO1-AI-37984/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV.
Next Document: Gay men who look for sex on the Internet: is there more HIV/STI risk with online partners?