Document Detail

Association between higher cumulative doses of recombinant erythropoietin and risk for retinopathy of prematurity.
MedLine Citation:
PMID:  16678749     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Retinopathy of prematurity is a complication of premature birth that varies in its severity. The incidence and severity of retinopathy of prematurity at our perinatal center in a regional referral hospital changed substantially during 1995 to 1998 and presented us with an opportunity to examine whether there was a protective effect on risk of retinopathy associated with exposure to recombinant erythropoietin. METHODS: We undertook a retrospective cohort study. From January 1995 through December 1998, charts of infants weighing<1500 g, who were 30 weeks' gestation or less, and who were admitted and survived to the first eye examination at 6 weeks were reviewed. Primary and secondary risk factors were recorded from the first 6 weeks of life. Of the eligible infants, 327 of 390 (84%) had complete records and retinal examinations. The probability for progression of retinopathy was estimated by logistic regression multivariate analysis using the continuation-ratio model. RESULTS: The overall incidence of retinopathy of prematurity was 36%. Recombinant erythropoietin exposure, as total 6-week dose, was independently associated with an increased risk for progression of retinopathy, OR=1.27 per 500 units/kg (95%CI=1.04, 1.55, P=0.02). Postnatal day of recombinant erythropoietin initiation also was associated with retinopathy risk but did not reach conventional statistical significance, OR=1.07 (CI=1.00, 1.14, P=0.07). CONCLUSIONS: These findings identify an association between cumulative recombinant erythropoietin exposure, used to reduce blood transfusions in premature infants, and an increased risk for retinopathy of prematurity. The nonhematopoietic properties of erythropoietin may account for the above findings, however further evaluation with confirmation is required.
Mark S Brown; Anna E Barón; Eric K France; Richard F Hamman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus     Volume:  10     ISSN:  1091-8531     ISO Abbreviation:  J AAPOS     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-07-17     Revised Date:  2009-10-23    
Medline Journal Info:
Nlm Unique ID:  9710011     Medline TA:  J AAPOS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
Department of Pediatrics, Presbyterian/St Luke's Medical Center, and Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, Colorado 80218, USA.
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MeSH Terms
Disease Progression
Erythropoietin, Recombinant / administration & dosage*
Gestational Age
Infant, Newborn
Infant, Very Low Birth Weight
Maternal Age
Multivariate Analysis
Retinopathy of Prematurity / etiology*,  physiopathology*
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Erythropoietin, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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