| Association between high-sensitivity cardiac troponin T levels and the predicted cardiovascular risk in middle-aged men without overt cardiovascular disease. | |
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MedLine Citation:
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PMID: 20569708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A slight elevation of cardiac troponin T (TnT) levels in the circulating blood can be detected by the recently developed, high-sensitivity TnT (hsTnT) assay. However, it remains unclear whether a slight elevation of hsTnT is associated with an increased cardiovascular risk in subjects without overt cardiovascular disease (CVD). METHODS: The serum hsTnT levels were measured in a work site-based population of 1,072 middle-aged males (mean age 44 years) without any history or presence of CVD. The lower detection limit of the hsTnT assay used in the present study was 0.002 ng/mL. The association of the hsTnT levels with cardiovascular risk factors and the predicted CVD risk, as determined by the Framingham CVD risk prediction score, were examined. RESULTS: Detectable hsTnT levels were seen in 867 subjects (80.9%). The highest value of the hsTnT was 0.020 ng/mL. Among various cardiovascular risk factors, age, blood pressure, estimated glomerular filtration rate, current smoking, and left ventricular hypertrophy were independent determinants of hsTnT levels. The odds ratio for a high predicted CVD risk (10-year risk > or =20%) in the highest tertile of hsTnT (> or =0.005 ng/mL) in comparison to the lowest tertile (< or =0.002 ng/mL) was 3.98 (95% CI 1.72-9.24, P = .001) after adjusting for multiple potential confounders. CONCLUSIONS: The present study showed the hsTnT levels to be significantly associated with several cardiovascular risk factors and the predicted CVD risk in middle-aged men without overt CVD, thus suggesting the usefulness of measuring hsTnT to identify high-risk subjects in the primary prevention of CVD. |
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Authors:
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Toshiaki Otsuka; Tomoyuki Kawada; Chikao Ibuki; Yoshihiko Seino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 159 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-07-15 Revised Date: 2010-12-22 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 972-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan. otsuka@nms.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Cardiovascular Diseases / blood*, epidemiology Follow-Up Studies Humans Immunoassay Incidence Japan / epidemiology Male Middle Aged Predictive Value of Tests Prognosis Questionnaires Retrospective Studies Risk Factors Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
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0/Troponin T |
| Comments/Corrections | |
Comment In:
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Am Heart J. 2010 Jun;159(6):933-6
[PMID:
20569702
]
Am Heart J. 2010 Dec;160(6):e47; author reply e49 [PMID: 21146648 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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